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dc.contributor.authorNieder, Carsten
dc.date.accessioned2020-03-30T08:42:55Z
dc.date.available2020-03-30T08:42:55Z
dc.date.issued2019-01-08
dc.description.abstractExcept for straightforward palliative indications such as painful bone metastases, re-irradiation is often characterized by a narrow therapeutic window and the potential for decreased efficacy and increased toxicity, especially if the cumulative total dose from both courses is high. Second re-irradiations tend to pose even bigger challenges and are thus offered in a restrictive manner to highly selected patients on a case-by-case basis. Normal tissue dose constraints are still an area of active investigation. Nevertheless, examples of potentially useful indications have been published. The present review briefly summarizes areas of uncertainty and opportunities for future research. If evidence-based concepts with acceptable side effect profiles can be developed, an increasing number of patients may benefit from additional radiotherapy to previously exposed target volumes.en_US
dc.identifier.citationNieder, C. (2019) Second re-irradiation: A delicate balance between safety and efficacy. <i>Physica medica (Testo stampato), 58, </i>, 155-158en_US
dc.identifier.cristinIDFRIDAID 1689475
dc.identifier.doi10.1016/j.ejmp.2019.01.004
dc.identifier.issn1120-1797
dc.identifier.issn1724-191X
dc.identifier.urihttps://hdl.handle.net/10037/17904
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.relation.journalPhysica medica (Testo stampato)
dc.rights.accessRightsopenAccessen_US
dc.rights.holder© 2019 Associazione Italiana di Fisica Medica. Published by Elsevier Ltd.en_US
dc.subjectVDP::Medical disciplines: 700::Clinical medical disciplines: 750::Oncology: 762en_US
dc.subjectVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Onkologi: 762en_US
dc.titleSecond re-irradiation: A delicate balance between safety and efficacyen_US
dc.type.versionacceptedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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