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dc.contributor.authorPandya, Abhilash D.
dc.contributor.authorØverbye, Anders
dc.contributor.authorSahariah, Priyanka
dc.contributor.authorGaware, Vivek S.
dc.contributor.authorHøgset, Håkon
dc.contributor.authorMasson, Már
dc.contributor.authorHøgset, Anders
dc.contributor.authorMælandsmo, Gunhild Mari
dc.contributor.authorSkotland, Tore
dc.contributor.authorSandvig, Kirsten
dc.contributor.authorIversen, Tore Geir
dc.date.accessioned2020-04-27T08:18:46Z
dc.date.available2020-04-27T08:18:46Z
dc.date.issued2020-02-24
dc.description.abstractIn this study we have developed biodegradable polymeric nanoparticles (NPs) containing the cytostatic drugs mertansine (MRT) or cabazitaxel (CBZ). The NPs are based on chitosan (CS) conjugate polymers synthesized with different amounts of the photosensitizer tetraphenylchlorin (TPC). These TPC–CS NPs have high loading capacity and strong drug retention due to π–π stacking interactions between the drugs and the aromatic photosensitizer groups of the polymers. CS polymers with 10% of the side chains containing TPC were found to be optimal in terms of drug loading capacity and NP stability. The TPC–CS NPs loaded with MRT or CBZ displayed higher cytotoxicity than the free form of these drugs in the breast cancer cell lines MDA-MB-231 and MDA-MB-468. Furthermore, light-induced photochemical activation of the NPs elicited a strong photodynamic therapy effect on these breast cancer cells. Biodistribution studies in mice showed that most of the TPC–CS NPs accumulated in liver and lungs, but they were also found to be localized in tumors derived from HCT-116 cells. These data suggest that the drug-loaded TPC–CS NPs have a potential in combinatory anticancer therapy and as contrast agents.en_US
dc.identifier.citationPandya AD, Øverbye A, Saharia, Gaware VS, Høgset H, Masson M, Høgset A, Mælandsmo GM, Skotland T, Sandvig K, Iversen TG. Drug-Loaded Photosensitizer-Chitosan Nanoparticles for Combinatorial Chemo- and Photodynamic-Therapy of Cancer. Biomacromolecules. 2020;21:1489-1498en_US
dc.identifier.cristinIDFRIDAID 1808042
dc.identifier.doi10.1021/acs.biomac.0c00061
dc.identifier.issn1525-7797
dc.identifier.issn1526-4602
dc.identifier.urihttps://hdl.handle.net/10037/18130
dc.language.isoengen_US
dc.publisherAmerican Chemical Societyen_US
dc.relation.journalBiomacromolecules
dc.relation.projectIDNorges forskningsråd: 228200en_US
dc.relation.projectIDinfo:eu-repo/granAgreement/RCN/NANO2021/228200/Norway/Biodegradable Nanoparticles in Cancer Diagnosis and Therapy//en_US
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2020 The Author(s)en_US
dc.subjectVDP::Medical disciplines: 700en_US
dc.subjectVDP::Medisinske Fag: 700en_US
dc.titleDrug-Loaded Photosensitizer-Chitosan Nanoparticles for Combinatorial Chemo- and Photodynamic-Therapy of Canceren_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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