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dc.contributor.authorIsaksen, Trond
dc.contributor.authorEvensen, Line Holtet
dc.contributor.authorBrækkan, Sigrid Kufaas
dc.contributor.authorHansen, John-Bjarne
dc.date.accessioned2020-04-29T08:51:23Z
dc.date.available2020-04-29T08:51:23Z
dc.date.issued2019-10-28
dc.description.abstract<i>Background</i> - Limited knowledge exists on the association between intake of long-chained n-3 polyunsaturated fatty acids (n-3 PUFAs) and risk of recurrence and all-cause mortality in patients with venous thromboembolism (VTE).<p><p> <i>Objectives</i> - This article investigates whether intake of marine n-3 PUFAs was associated with risk of recurrence and mortality in patients with incident VTE.<p><p> <i>Methods</i> - A total of 595 patients with incident VTE and available data on n-3 PUFA intake were derived from the Tromsø Study surveys 4 (1994–1995) and 6 (2007–2008). Weekly intake of n-3 PUFAs was categorized as low, medium, and high based on tertiles. Recurrent VTEs and all-cause mortality were registered up to December 31, 2016. Hazard ratios (HRs) were calculated using Cox regression models with the low intake category as reference.<p><p> <i>Results</i> - There were 98 recurrent VTEs and 227 deaths during follow-up. Overall, we found no association between intake of n-3 PUFAs and risk of recurrent VTE. However, inverse associations were found for high intakes in patients with unprovoked VTE (HR 0.45, 95% confidence interval [CI]: 0.20–1.01), cancer-free patients (HR 0.51, 95% CI: 0.27–0.95), and deep vein thrombosis (DVT) patients (HR 0.49, 95% CI: 0.24–0.97). The inverse associations were more evident when follow-up was restricted to the time after discontinuation of anticoagulant therapy. No association was observed between intake of n-3 PUFAs and mortality after incident VTE.<p><p> <i>Conclusion</i> - A high dietary intake of marine n-3 PUFAs was associated with lower risk of recurrent VTE after unprovoked index events, DVT, and in cancer-free patients.en_US
dc.identifier.citationIsaksen T, Evensen L, Brækkan SK, Hansen JB. Dietary Intake of Marine Polyunsaturated n-3 Fatty Acids and Risk of Recurrent Venous Thromboembolism. Thrombosis and Haemostasis. 2019;119(12):2053-2063en_US
dc.identifier.cristinIDFRIDAID 1770164
dc.identifier.doi10.1055/s-0039-1697663
dc.identifier.issn0340-6245
dc.identifier.urihttps://hdl.handle.net/10037/18156
dc.language.isoengen_US
dc.publisherThieme Publishingen_US
dc.relation.ispartofIsaksen, T. (2020). Dietary intake of marine polyunsaturated fatty acids and incidence, recurrence and mortality related to venous thromboembolism. (Doctoral thesis). <a href=https://hdl.handle.net/10037/19730>https://hdl.handle.net/10037/19730</a>.
dc.relation.journalThrombosis and Haemostasis
dc.rights.accessRightsopenAccessen_US
dc.rights.holder© 2019 Georg Thieme Verlag KGen_US
dc.subjectVDP::Medical disciplines: 700en_US
dc.subjectVDP::Medisinske Fag: 700en_US
dc.titleDietary Intake of Marine Polyunsaturated n-3 Fatty Acids and Risk of Recurrent Venous Thromboembolismen_US
dc.type.versionacceptedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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