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dc.contributor.authorEksteen, Jacobus Johannes
dc.contributor.authorAusbacher, Dominik
dc.contributor.authorVasskog, Terje
dc.contributor.authorRekdal, Øystein
dc.contributor.authorSvendsen, John Sigurd Mjøen
dc.date.accessioned2020-06-17T12:10:49Z
dc.date.available2020-06-17T12:10:49Z
dc.date.issued2020-03-06
dc.description.abstractShort histidine-rich peptides could serve as novel activatable vectors for delivering cytotoxic payloads to tumor and neovasculature cells. This explorative study reports preliminary results showing that zinc ions, which are found in elevated levels at neovasculature sites, can trigger the intracellular delivery of a short antimicrobial peptide when conjugated to a histidine-rich peptide through a disulfide bond. The importance of exofacial thiols in the mode of action of these disulfide-linked conjugates is also shown.en_US
dc.identifier.citationEksteen JJ, Ausbacher D, Vasskog TV, Rekdal Ø, Svendsen JS. Selective intracellular delivery of thiolated cargo to tumor and neovasculature cells using histidine-rich peptides as vectors . ACS Omega. 2020;5(10):4937-4942en_US
dc.identifier.cristinIDFRIDAID 1807477
dc.identifier.doi10.1021/acsomega.9b00700
dc.identifier.issn2470-1343
dc.identifier.urihttps://hdl.handle.net/10037/18589
dc.language.isoengen_US
dc.publisherAmerican Chemical Societyen_US
dc.relation.journalACS Omega
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2020 American Chemical Societyen_US
dc.subjectVDP::Medical disciplines: 700::Clinical medical disciplines: 750::Oncology: 762en_US
dc.subjectVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Onkologi: 762en_US
dc.titleSelective intracellular delivery of thiolated cargo to tumor and neovasculature cells using histidine-rich peptides as vectorsen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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