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dc.contributor.authorPage, Christian
dc.contributor.authorDjordjilovic, Vera
dc.contributor.authorNøst, Therese Haugdahl
dc.contributor.authorGhiasvand, Reza
dc.contributor.authorSandanger, Torkjel M
dc.contributor.authorFrigessi Di Rattalma, Arnoldo
dc.contributor.authorThoresen, Magne
dc.contributor.authorVeierød, Marit Bragelien
dc.date.accessioned2020-06-24T07:00:32Z
dc.date.available2020-06-24T07:00:32Z
dc.date.issued2020-03-11
dc.description.abstractUltraviolet radiation (UVR) exposure is a leading cause of skin cancers and an ubiquitous environmental exposure. However, the molecular mechanisms relating UVR exposure to melanoma is not fully understood. We aimed to investigate if lifetime UVR exposure could be robustly associated to DNA methylation (DNAm). We assessed DNAm in whole blood in three data sets (n = 183, 191, and 125) from the Norwegian Woman and Cancer cohort, using Illumina platforms. We studied genome-wide DNAm, targeted analyses of CpG sites indicated in the literature, global methylation, and accelerated aging. Lifetime history of UVR exposure (residential ambient UVR, sunburns, sunbathing vacations and indoor tanning) was collected by questionnaires. We used one data set for discovery and the other two for replication. One CpG site showed a genome-wide significant association to cumulative UVR exposure (cg01884057) (pnominal = 3.96e-08), but was not replicated in any of the two replication sets (pnominal ≥ 0.42). Two CpG sites (cg05860019, cg00033666) showed suggestive associations with the other UVR exposures. We performed extensive analyses of the association between long-term UVR exposure and DNAm. There was no indication of a robust effect of past UVR exposure on DNAm.en_US
dc.identifier.citationPage CM, Djordjilovic V, Nøst TH, Ghiasvand R, Sandanger TM, Frigessi Di Rattalma A, Thoresen M, Veierød MB. Lifetime ultraviolet radiation exposure and DNA methylation in blood leukocytes: The Norwegian Women and Cancer Study. Scientific Reports. 2020;10:4521:1-8en_US
dc.identifier.cristinIDFRIDAID 1813492
dc.identifier.doi10.1038/s41598-020-61430-3
dc.identifier.issn2045-2322
dc.identifier.urihttps://hdl.handle.net/10037/18637
dc.language.isoengen_US
dc.publisherSpringer Natureen_US
dc.relation.journalScientific Reports
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/FP7/232997/EU/Transcriptomics in Cancer Epidemiology/TICE/en_US
dc.relation.projectIDinfo:eu-repo/grantAgreement/RCN/BEHANDLING/248804/Norway/National training initiative to make better use of biobanks and health registry data//en_US
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2020 The Author(s)en_US
dc.subjectVDP::Medical disciplines: 700::Clinical medical disciplines: 750::Oncology: 762en_US
dc.subjectVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Onkologi: 762en_US
dc.titleLifetime ultraviolet radiation exposure and DNA methylation in blood leukocytes: The Norwegian Women and Cancer Studyen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US


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