Show simple item record

dc.contributor.authorAimo, Alberto
dc.contributor.authorJanuzzi, James L.
dc.contributor.authorVergaro, Giuseppe
dc.contributor.authorRichards, A. Mark
dc.contributor.authorLam, Carolyn S.P.
dc.contributor.authorLatini, Roberto
dc.contributor.authorAnand, Inder S.
dc.contributor.authorCohn, Jay N.
dc.contributor.authorUeland, Thor
dc.contributor.authorGullestad, Lars
dc.contributor.authorAukrust, Pål
dc.contributor.authorBrunner-La Rocca, Hans-Peter
dc.contributor.authorBayes-Genis, Antoni
dc.contributor.authorLupón, Josep
dc.contributor.authorde Boer, Rudolf A.
dc.contributor.authorTakeishi, Yasuchika
dc.contributor.authorEgstrup, Michael
dc.contributor.authorGustafsson, Ida
dc.contributor.authorGaggin, Hanna K.
dc.contributor.authorEggers, Kai M.
dc.contributor.authorHuber, Kurt
dc.contributor.authorGamble, Greg D.
dc.contributor.authorLing, Lieng H.
dc.contributor.authorLeong, Kui Tong Gerard
dc.contributor.authorYeo, Poh Shuah Daniel
dc.contributor.authorOng, Hean Yee
dc.contributor.authorJaufeerally, Fazlur
dc.contributor.authorNg, Tze P.
dc.contributor.authorTroughton, Richard
dc.contributor.authorDoughty, Robert N.
dc.contributor.authorPassino, Claudio
dc.contributor.authorEmdin, Michele
dc.date.accessioned2020-07-02T09:23:56Z
dc.date.available2020-07-02T09:23:56Z
dc.date.issued2020-01-09
dc.description.abstract<i>Aims</i> - N‐terminal pro‐B‐type natriuretic peptide (NT‐proBNP), high‐sensitivity troponin T (hs‐TnT) and soluble suppression of tumorigenesis‐2 (sST2) predict outcome in chronic heart failure (HF). We assessed the influence of age on circulating levels and prognostic significance of these biomarkers.<p> <p><i>Methods and results</i> - Individual data from 5301 patients with chronic HF and NT‐proBNP, hs‐TnT, and sST2 data were evaluated. Patients were stratified according to age: <60 years (n = 1332, 25%), 60–69 years (n = 1628, 31%), 70–79 years (n = 1662, 31%), and ≥ 80 years (n = 679, 13%). Patients (median age 66 years, 75% men, median left ventricular ejection fraction 28%, 64% with ischaemic HF) had median NT‐proBNP 1564 ng/L, hs‐TnT 21 ng/L, and sST2 29 ng/mL. Age independently predicted NT‐proBNP and hs‐TnT, but not sST2. The best NT‐proBNP and hs‐TnT cut‐offs for 1‐year and 5‐year all‐cause and cardiovascular mortality and 1‐ to 12‐month HF hospitalization increased with age, while the best sST2 cut‐offs did not. When stratifying patients according to age‐ and outcome‐specific cut‐offs, this stratification yielded independent prognostic significance over NT‐proBNP levels only, or the composite of NT‐proBNP and hs‐TnT, and improved risk prediction for most endpoints. Finally, absolute NT‐proBNP, hs‐TnT, and sST2 levels predicted outcomes independent of age, sex, left ventricular ejection fraction category, ethnic group, and other variables.<p> <p><i>Conclusions</i> - Soluble ST2 is less influenced by age than NT‐proBNP or hs‐TnT; all these biomarkers predict outcome regardless of age. The use of age‐ and outcome‐specific cut‐offs of NT‐proBNP, hs‐TnT and sST2 allows more accurate risk stratification than NT‐proBNP alone or the combination of NT‐proBNP and hs‐TnT.en_US
dc.descriptionThis is the peer reviewed version of the following article: Aimo, A., Januzzi, J.L., Vergaro, G., Richards, A.M., Lam, C.S.P., Latini, R. ... Emdin, M. (2020). Circulating levels and prognostic value of soluble ST2 in heart failure are less influenced by age than N-terminal pro-B-type natriuretic peptide and high-sensitivity troponin T, <i>European Journal of Heart Failure</i>, which has been published in final form at <a href=https://doi.org/10.1002/ejhf.1701>https://doi.org/10.1002/ejhf.1701. </a>. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.en_US
dc.identifier.citationAimo, A., Januzzi, J.L., Vergaro, G., Richards, A.M., Lam, C.S.P., Latini, R. ... Emdin, M. (2020). Circulating levels and prognostic value of soluble ST2 in heart failure are less influenced by age than N-terminal pro-B-type natriuretic peptide and high-sensitivity troponin T, <i>European Journal of Heart Failure</i>.en_US
dc.identifier.cristinIDFRIDAID 1816430
dc.identifier.doi10.1002/ejhf.1701
dc.identifier.issn1388-9842
dc.identifier.issn1879-0844
dc.identifier.urihttps://hdl.handle.net/10037/18748
dc.language.isoengen_US
dc.publisherWileyen_US
dc.relation.journalEuropean Journal of Heart Failure
dc.rights.accessRightsopenAccessen_US
dc.rights.holder© 2020 The Authors European Journal of Heart Failure © 2020 European Society of Cardiologyen_US
dc.subjectVDP::Medical disciplines: 700::Basic medical, dental and veterinary science disciplines: 710en_US
dc.subjectVDP::Medisinske Fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710en_US
dc.titleCirculating levels and prognostic value of soluble ST2 in heart failure are less influenced by age than N-terminal pro-B-type natriuretic peptide and high-sensitivity troponin Ten_US
dc.type.versionacceptedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


File(s) in this item

Thumbnail

This item appears in the following collection(s)

Show simple item record