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dc.contributor.authorVillatoro, Alicia
dc.contributor.authorKonieczny, Joanna
dc.contributor.authorCuminetti, Vincent
dc.contributor.authorArranz, Lorena
dc.date.accessioned2020-08-11T11:21:41Z
dc.date.available2020-08-11T11:21:41Z
dc.date.issued2020-07-09
dc.description.abstractAcute myeloid leukemia (AML) is a heterogeneous, complex, and deadly disease, whose treatment has hardly evolved for decades and grounds on the use of intensive chemotherapy regimens. Chemotherapy helps reduce AML bulk, but promotes relapse in the long-run by selection of chemoresistant leukemia stem cells (LSC). These may diversify and result in progression to more aggressive forms of AML. <i>In vivo</i> models suggest that the bone marrow stem cell niche helps LSC stay dormant and protected from chemotherapy. Here, we summarize relevant changes in stem cell niche homing and adhesion of AML LSC vs. healthy hematopoietic stem cells, and provide an overview of clinical trials aiming at targeting these processes for AML treatment and future directions within this field. Promising results with various non-mutation-targeted novel therapies directed to LSC eradication via interference with their anchoring to the stem cell niche have encouraged on-going or future advanced phase III clinical trials. In the coming years, we may see a shift in the focus of AML treatment to LSC-directed therapies if the prospect of improved cure rates holds true. In the future, AML treatment should lean toward personalized therapies using combinations of these compounds plus mutation-targeted agents and/or targeted delivery of chemotherapy, aiming at LSC eradication with reduced side effects.en_US
dc.identifier.citationVillatoro A, Konieczny J, Cuminetti V, Arranz L. Leukemia Stem Cell Release From the Stem Cell Niche to Treat Acute Myeloid Leukemia. Frontiers in Cell and Developmental Biology. 2020;8:607en_US
dc.identifier.cristinIDFRIDAID 1821914
dc.identifier.doi10.3389/fcell.2020.00607
dc.identifier.issn2296-634X
dc.identifier.urihttps://hdl.handle.net/10037/18948
dc.language.isoengen_US
dc.publisherFrontiers Mediaen_US
dc.relation.journalFrontiers in Cell and Developmental Biology
dc.relation.projectIDinfo:eu-repo/grantAgreement/RCN/BEHANDLING/247596/Norway/Neuroglial Regulation of the Haematopoietic Stem Cell Niche in Acute Myeloid Leukaemia Transformation//en_US
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2020 The Author(s)en_US
dc.subjectVDP::Medical disciplines: 700en_US
dc.subjectVDP::Medisinske Fag: 700en_US
dc.titleLeukemia Stem Cell Release From the Stem Cell Niche to Treat Acute Myeloid Leukemiaen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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