The emergence of antibiotic resistant bacterial strains is a rising global problem that does not only result in fatal infections of previously treatable cases, but increases also the economic burden of health care systems. The same applies for cancer as treatment of some cancer types is difficult and also resistance to treatment is an increasing problem in cancer chemotherapy. Novel treatment ...

Background: In a project at UiT - the Arctic University of Norway, the lipid profile of the microalgal biomass from the specie Porosira glacialis is mapped using HRMS lipidomic analyses to evaluate the potential for the biomass to be used as fish feed. At the same time, it is desired to screen the same biomass for bioactivities using bioassays in combination with HRMS metabolomic analyses. ...

Today, Wikipedia has developed into a prominent source for health queries to the vast public. Over the years, some studies have been performed to understand what the webpage can and cannot offer. However, the current literature lacks knowledge of how the pharmaceutical industry is present in Wikipedia’s medicine articles. The immediate objective of this research was to quantify the presence of ...

Many of the anticancer compounds discovered through synthesis or bioprospecting activities are found to be equally toxic to healthy cells and tumors. Consequently, these compounds are not considered as promising drug candidates worthy of further study. This project seeks to develop a novel chemical toolkit that can be utilized to increase the therapeutic value of such toxic compounds by decreasing ...

Total parenteral ernæring (TPN) gis forebyggende eller korrigerende mot feilernæring til pasienter hvor oral eller enteral ernæring vanskelig lar seg gjøre. TPN inneholder glukose, fett og aminorsyrer i tillegg til viktige vitaminer, sporelementer og elektrolytter. TPN er en steril olje-i-vann (o/v) emulsjon, stabilisert ved hjelp av en lecitin-emulgator. Scenario hvor legemiddel og TPN må administreres ...

The exposure to pollutants is a serious and increasing health problem, which has been associated with increased morbidity and mortality among people. Many toxic compounds can accumulate in the environment and evidence suggests that most people have varying degrees of toxic compounds within their body. This can result in disruption of many physiological processes in the human body and the development ...

Background: Familial adenomatous polyposis (FAP) is a hereditary autosomal dominant condition characterized by the appearance of hundreds to thousands of adenomatous polyps throughout the colon and rectum. If the condition is left untreated it will ultimately develop into colorectal cancer. Most of the articles available today concerning FAP focus on the adenomatous polyposis coli gene as this gene ...

Oxytocin has been shown to be implicated in psychiatric diseases such as depression, anxiety disorders, autism post-traumatic stress disorder, and schizophrenia. As a result, oxytocin can be used as a potential treatment for these brain disorders. However, oxytocin is a large peptide, and is therefore unable to cross the blood brain barrier. Thus, the development of new small non-peptide drugs would ...

Dopamine and serotonin are two neurotransmitters that exert their actions through mediation of dopaminergic and serotonergic receptors respectively. The receptors in focus in the current study, are the dopamine D2 and serotonin 5-HT2A receptors. Common for both receptors is that they are class A G-protein-coupled receptors consisting of seven transmembrane helices embedded in the lipid membrane of ...

The enzyme UDP-glucuronosyltransferase 2B17 (UGT2B17) has a major role in androgen metabolism, being involved in the conjugation of both testosterone and its potent metabolite dihydrotestosterone. The enzyme catalyses the transfer of glucuronic acid from UDP-glucuronic acid to the lipophilic androgen substrate. As a consequence, the water solubility of the substrate is increased, and it is more ...