<p><i>Background</i> At present time, antimicrobial resistance is emerging more rapidly than the development of novel antimicrobials, presenting a serious threat to how we prevent and treat infectious diseases. Several treatment strategies to counteract this development have been proposed, among these is the use of collateral sensitivity in clinical treatment. The ability to predict collateral ...

Bakgrunn og formål: I den norske befolkningen er det et relativt stort bruk av legemidler. Bruk av legemidler kan føre til legemiddelfeil og legemiddelrelaterte problemer. Dette kan skje under informasjonsoverføring mellom omsorgsnivå som fra fastlege til sykehjem, eller også i samme enhet som mellom sykehusavdelinger. Mange av pasientskadene på sykehus er legemiddelrelaterte og mange innleggelser ...

In recent years, many pathogenic bacteria have developed resistance against the existing antimicrobials, a phenomenon known as antimicrobial resistance (AMR). One of the many reasons contributing to the observed failure of current therapies, is the poor drug penetration across the microbial biofilm. Biofilms are small structural communities of bacterial cells that excrete an extracellular polymeric ...

Antimicrobial resistance has been a challenge ever since the discovery of antibiotics. The rising challenge of resistance has led to the increased use of last-resort antibiotics: carbapenems. It is predicted that a successful E. coli clone, ST131 is apt for the acquisition of carbapenem-resistance encoding plasmids. In this study, we aim to understand how E. coli ST131 respond to acquisition of ...

<p>Recent studies have highlighted the clinical benefits of regulating phosphodiesterase-3 enzymes. Inhibition of PDE3A has proven to aid in preventing and treating cardiovascularrelated disorders and platelet dysfunction. Hypothermia is a condition that can cause cardiac arrest. However, there are no suitable inotropic drugs that are effective for use under hypothermic conditions. Being able to ...

While targeted therapy exists for ER-positive breast cancers, the treatment option for TNBC is conventional chemotherapy giving a poorer prognosis. It is therefore of interest to study molecular mechanisms and differences between MCF7 (ER-positive) and MDA-MB-231 (ER, PR, and HER2- negative). These cell lines are in vitro representative models for luminal A (non-aggressive) and basal-like (aggressive) ...

Skin and soft tissue infections (SSTIs) and chronic wounds are major challenges for the healthcare system worldwide. The additional rapid development of antibacterial resistance and lack of successful treatment strategies increase the chance for infected chronic wounds to be fatal for the patient. Therefore, there is a need for more efficient dermal antimicrobial therapies. A class of promising ...

γ-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the CNS. GABA exerts its function on both ionotropic ligand-gated GABAA receptors and metabotropic GABAB G-protein coupled receptors (GPCRs). Disruption in the GABAergic system has been associated with numerous neurological and psychiatric disorders in humans. These include developmental dysfunctions, epilepsy, sleep disorders, ...

Bakgrunn: Ettårig periodeprevalens for bruk av antibakterielle midler til barn i Norge er høyest før tre års alder. Forskriving av antibakterielle midler påvirkes av mange faktorer, og kartlegging av disse kan gi mulighet til å målrette intervensjoner for å redusere forskriving. Formål: De primære målene var å undersøke om fødselssesong predikerer alder ved første utlevering av antibakterielle midler, ...

In vitro lipolysis models are commonly used to assess the performance of lipid-based drug delivery systems (LbDDSs) in terms of their drug absorption potential; however, this in vitro approach has not always shown to correlate well with in vivo data. Several studies suggest that adding an absorption step to the in vitro lipolysis model would give a better estimation of absorption for drugs incorporated ...