Show simple item record

dc.contributor.authorThorvaldsen, Steinar
dc.contributor.authorHössjer, Ola
dc.date.accessioned2020-10-09T09:49:02Z
dc.date.available2020-10-09T09:49:02Z
dc.date.issued2020-06-04
dc.description.abstractFine-tuning has received much attention in physics, and it states that the fundamental constants of physics are finely tuned to precise values for a rich chemistry and life permittance. It has not yet been applied in a broad manner to molecular biology. However, in this paper we argue that biological systems present fine-tuning at different levels, e.g. functional proteins, complex biochemical machines in living cells, and cellular networks. This paper describes molecular fine-tuning, how it can be used in biology, and how it challenges conventional Darwinian thinking. We also discuss the statistical methods underpinning fine-tuning and present a framework for such analysis.en_US
dc.identifier.citationThorvaldsen S, Hössjer O. Using statistical methods to model the fine-tuning of molecular machines and systems. Journal of Theoretical Biology. 2020;501:1-14en_US
dc.identifier.cristinIDFRIDAID 1838210
dc.identifier.doihttps://doi.org/10.1016/j.jtbi.2020.110352
dc.identifier.issn0022-5193
dc.identifier.issn1095-8541
dc.identifier.urihttps://hdl.handle.net/10037/19569
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.relation.journalJournal of Theoretical Biology
dc.relation.urihttps://www.sciencedirect.com/science/article/pii/S0022519320302071/pdf
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2020 The Author(s)en_US
dc.subjectVDP::Mathematics and natural science: 400::Mathematics: 410en_US
dc.subjectVDP::Matematikk og Naturvitenskap: 400::Matematikk: 410en_US
dc.titleUsing statistical methods to model the fine-tuning of molecular machines and systemsen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US


File(s) in this item

Thumbnail

This item appears in the following collection(s)

Show simple item record