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dc.contributor.authorSøland, Tine Merete
dc.contributor.authorBjerkli, Inger-Heidi
dc.contributor.authorGeorgsen, Jeanette B
dc.contributor.authorSchreurs, Olaf Joseph Franciscus
dc.contributor.authorJebsen, Peter Wilhelm
dc.contributor.authorLaurvik, Helene
dc.contributor.authorSapkota, Dipak
dc.date.accessioned2020-11-04T08:35:04Z
dc.date.available2020-11-04T08:35:04Z
dc.date.issued2020-11-03
dc.description.abstract<p><i>Objectives - </i>The presence of and the causative role of high‐risk human papilloma virus (HPV) is a subject of controversy in oral squamous cell carcinoma (OSCC). The disagreement can be related to the misclassification of OSCC as oropharyngeal squamous cell carcinoma and/or lack of standard detection methods. This study aimed to examine the presence of transcriptionally active high‐risk HPV in a homogenous Norwegian cohort of primary and second primary OSCC of the mobile tongue (oral tongue squamous cell carcinoma—OTSCC). <p><i>Methods - </i>Tissue microarrays containing formalin‐fixed and paraffin‐embedded cores of 146 OTSCC from the anterior 2/3 of the tongue (n = 128 primary and n = 18 second primary) from a multicentric Norwegian cohort were examined for the presence of high‐risk HPV by DNA‐ and RNA‐in situ hybridization (ISH) assays and p16 immunohistochemistry. <p><i>Results -</i>Transcriptionally active HPV (E6/E7 mRNA) was not identified in any of the OTSCC specimens. In parallel, no tumors were positive for HPV by DNA ISH. Although, 61 (42%) OTSCC demonstrated p16 positivity with varying staining intensity and subcellular localization, only two cases demonstrated strong and uniform p16‐staining (both cytoplasmic and nuclear) in >70% of cancer cells. The absence of transcriptionally active high‐risk HPV in this cohort of OTSCC indicates that high‐risk HPV is an unlikely causative factor in the present material.en_US
dc.identifier.citationSøland, Bjerkli, Georgsen, Schreurs, Jebsen, Laurvik, Sapkota. High-risk human papilloma virus was not detected in a Norwegian cohort of oral squamous cell carcinoma of the mobile tongue. Clinical and Experimental Dental Research. 2020en_US
dc.identifier.cristinIDFRIDAID 1844535
dc.identifier.doi10.1002/cre2.342
dc.identifier.issn2057-4347
dc.identifier.urihttps://hdl.handle.net/10037/19756
dc.language.isoengen_US
dc.publisherWileyen_US
dc.relation.ispartofBjerkli, I.H. (2020). Prognostic indicators of survival for patients with oral cavity squamous cell carcinoma in Norway. Outcomes in a retrospective, multicenter cohort, with special focus on oral tongue squamous cell carcinoma, 2005-2009. (Doctoral thesis). <a href=https://hdl.handle.net/10037/19390>https://hdl.handle.net/10037/19390</a>.
dc.relation.journalClinical and Experimental Dental Research
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2020 The Author(s)en_US
dc.subjectVDP::Medical disciplines: 700::Clinical medical disciplines: 750::Oncology: 762en_US
dc.subjectVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Onkologi: 762en_US
dc.subjectVDP::Medical disciplines: 700::Clinical dentistry disciplines: 830en_US
dc.subjectVDP::Medisinske Fag: 700::Klinisk odontologiske fag: 830en_US
dc.titleHigh-risk human papilloma virus was not detected in a Norwegian cohort of oral squamous cell carcinoma of the mobile tongueen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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