Blar i forfatter Mastergradsoppgaver i biologi (Helsefak) "Granaas, Magnus Løkke"
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Development of an assay for determining PDE5 enzyme activity and for screening of potential inhibitors of the PDE5 enzyme in cancer cells
Granaas, Magnus Løkke (Master thesis; Mastergradsoppgave, 2013-05-15)PDE5 is a member of the superfamily of phosphodiesterases, and it is identified as the main mechanism for breakdown of cGMP in mammals. Sildenafil is a well-known inhibitor of the PDE5 enzyme and it is also shown that sildenafil inhibits the ABCC5 transporter pump. ABCC5 is a member of the superfamily of ABC-transporters, and identified as an important transporter for mediating the cellular efflux ...