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dc.contributor.authorRagunathan, Kalaiyarasi
dc.contributor.authorEsnardo Upfold, Nikki Lyn
dc.contributor.authorOksenych, Valentyn
dc.date.accessioned2020-12-08T13:26:04Z
dc.date.available2020-12-08T13:26:04Z
dc.date.issued2020-11-16
dc.description.abstractCancer-associated fibroblasts (CAF) form the basis of tumor microenvironment and possess immunomodulatory functions by interacting with other cells surrounding tumor, including T lymphocytes, macrophages, dendritic cells and natural killer cells. Ionizing radiation is a broadly-used method in radiotherapy to target tumors. In mammalian cells, ionizing radiation induces various types of DNA damages and DNA damage response. Being unspecific, radiotherapy affects all the cells in tumor microenvironment, including the tumor itself, CAFs and immune cells. CAFs are extremely radio-resistant and do not initiate apoptosis even at high doses of radiation. However, following radiation, CAFs become senescent and produce a distinct combination of immunoregulatory molecules. Radiosensitivity of immune cells varies depending on the cell type due to inefficient DNA repair in, for example, monocytes and granulocytes. In this minireview, we are summarizing recent findings on the interaction between CAF, ionizing radiation and immune cells in the tumor microenvironment.en_US
dc.identifier.citationRagunathan, Esnardo Upfold, Oksenych. Interaction between Fibroblasts and Immune Cells Following DNA Damage Induced by Ionizing Radiation. International Journal of Molecular Sciences. 2020en_US
dc.identifier.cristinIDFRIDAID 1850746
dc.identifier.doi10.3390/ijms21228635
dc.identifier.issn1422-0067
dc.identifier.urihttps://hdl.handle.net/10037/20027
dc.language.isoengen_US
dc.publisherMDPIen_US
dc.relation.journalInternational Journal of Molecular Sciences
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2020 The Author(s)en_US
dc.subjectVDP::Medical disciplines: 700::Clinical medical disciplines: 750::Oncology: 762en_US
dc.subjectVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Onkologi: 762en_US
dc.titleInteraction between Fibroblasts and Immune Cells Following DNA Damage Induced by Ionizing Radiationen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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