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dc.contributor.authorBergland, Anne Katrine
dc.contributor.authorProitsi, Petroula
dc.contributor.authorKirsebom, Bjørn-Eivind
dc.contributor.authorSønnesyn, Hogne
dc.contributor.authorHye, Abdul
dc.contributor.authorLarsen, Alf Inge
dc.contributor.authorXu, Jin
dc.contributor.authorLegido-Quigley, Cristina
dc.contributor.authorRajendran, Lawrence
dc.contributor.authorFladby, Tormod
dc.contributor.authorAarsland, Dag
dc.date.accessioned2021-01-07T14:25:39Z
dc.date.available2021-01-07T14:25:39Z
dc.date.issued2020-09-29
dc.description.abstract<p><i>Background: </i>Lipids have important structural roles in cell membranes and changes to these membrane lipids may influence β- and γ-secretase activities and thus contribute to Alzheimer’s disease (AD) pathology. <p><i>Objective:</i> To explore baseline plasma lipid profiling in participants with mild cognitive impairment (MCI) with and without AD pathology. <p><i>Methods: </i>We identified 261 plasma lipids using reversed-phase liquid chromatography/mass spectrometry in cerebrospinal fluid amyloid positive (Aβ+) or negative (Aβ–) participants with MCI as compared to controls. Additionally, we analyzed the potential associations of plasma lipid profiles with performance on neuropsychological tests at baseline and after two years. <p><i>Results: </i>Sphingomyelin (SM) concentrations, particularly, SM(d43:2), were lower in MCI Aβ+ individuals compared to controls. Further, SM(d43:2) was also nominally reduced in MCI Aβ+ individuals compared to MCI Aβ–. No plasma lipids were associated with performance on primary neuropsychological tests at baseline or between the two time points after correction for multiple testing. <p><i>Conclusion: </i>Reduced plasma concentrations of SM were associated with AD.en_US
dc.identifier.citationBergland, A.K., Proitsi, P., Kirsebom, B.-E., Soennesyn, H., Hye, A., Larsen, A.I., ... Aarsland, D. (2020). Exploration of Plasma Lipids in Mild Cognitive Impairment due to Alzheimer’s Disease. <i>Journal of Alzheimer's Disease, 77</i>(3), 1117-1127.en_US
dc.identifier.doi10.3233/JAD-200441
dc.identifier.urihttps://hdl.handle.net/10037/20202
dc.language.isoengen_US
dc.publisherIOS Pressen_US
dc.relation.journalJournal of Alzheimer's Disease
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2020 The Author(s)en_US
dc.subjectVDP::Medical disciplines: 700::Clinical medical disciplines: 750::Geriatrics: 778en_US
dc.subjectVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Geriatri: 778en_US
dc.titleExploration of plasma lipids in mild cognitive impairment due to Alzheimer's diseaseen_US
dc.type.versionsubmittedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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