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dc.contributor.authorSchoemaker, Minouk J.
dc.contributor.authorNichols, Hazel B.
dc.contributor.authorWright, Lauren B.
dc.contributor.authorBrook, Mark N.
dc.contributor.authorJones, Michael E.
dc.contributor.authorO'Brien, Katie M.
dc.contributor.authorAdami, Hans Olov
dc.contributor.authorBaglietto, Laura
dc.contributor.authorBernstein, Leslie
dc.contributor.authorBertrand, Kimberly A.
dc.contributor.authorBoutron-Ruault, Marie-Christine
dc.contributor.authorChen, Yu
dc.contributor.authorConnor, Avonne E.
dc.contributor.authorDossus, Laure
dc.contributor.authorEliassen, A. Heather
dc.contributor.authorGiles, Graham G
dc.contributor.authorGram, Inger Torhild
dc.contributor.authorHankinson, Susan E.
dc.contributor.authorKaaks, Rudolf
dc.contributor.authorKey, Timothy J.
dc.contributor.authorKirsh, Victoria A.
dc.contributor.authorKitahara, Cari M.
dc.contributor.authorLarsson, Susanna C.
dc.contributor.authorLinet, Martha
dc.contributor.authorMa, Huiyan
dc.contributor.authorMilne, Roger L.
dc.contributor.authorOzasa, Kotaro
dc.contributor.authorPalmer, Julie R.
dc.contributor.authorRiboli, Elio
dc.contributor.authorRohan, Thomas E.
dc.contributor.authorSacerdote, Carlotta
dc.contributor.authorSadakane, Atsuko
dc.contributor.authorSund, Malin
dc.contributor.authorTamimi, Rulla M.
dc.contributor.authorTrichopoulou, Antonia
dc.contributor.authorUrsin, Giske
dc.contributor.authorVisvanathan, Kala
dc.contributor.authorWeiderpass, Elisabete
dc.contributor.authorWillett, Walter C.
dc.contributor.authorWolk, Alicja
dc.contributor.authorZeleniuch-Jacquotte, Anne
dc.contributor.authorSandler, Dale P.
dc.contributor.authorSwerdlow, Anthony J.
dc.date.accessioned2021-01-08T10:00:13Z
dc.date.available2021-01-08T10:00:13Z
dc.date.issued2020-02-03
dc.description.abstractEarly‐adulthood body size is strongly inversely associated with risk of premenopausal breast cancer. It is unclear whether subsequent changes in weight affect risk. We pooled individual‐level data from 17 prospective studies to investigate the association of weight change with premenopausal breast cancer risk, considering strata of initial weight, timing of weight change, other breast cancer risk factors and breast cancer subtype. Hazard ratios (HR) and 95% confidence intervals (CI) were obtained using Cox regression. Among 628,463 women, 10,886 were diagnosed with breast cancer before menopause. Models adjusted for initial weight at ages 18–24 years and other breast cancer risk factors showed that weight gain from ages 18–24 to 35–44 or to 45–54 years was inversely associated with breast cancer overall (e.g., HR per 5 kg to ages 45–54: 0.96, 95% CI: 0.95–0.98) and with oestrogen‐receptor(ER)‐positive breast cancer (HR per 5 kg to ages 45–54: 0.96, 95% CI: 0.94–0.98). Weight gain from ages 25–34 was inversely associated with ER‐positive breast cancer only and weight gain from ages 35–44 was not associated with risk. None of these weight gains were associated with ER‐negative breast cancer. Weight loss was not consistently associated with overall or ER‐specific risk after adjusting for initial weight. Weight increase from early‐adulthood to ages 45–54 years is associated with a reduced premenopausal breast cancer risk independently of early‐adulthood weight. Biological explanations are needed to account for these two separate factors.en_US
dc.identifier.citationSchoemaker, M.J., Nichols, H.B., Wright, L.B., Brook, M.N., Jones, M.E., O'Brien, K.M. ... Swerdlow, A.J. (2020). Adult weight change and premenopausal breast cancer risk: A prospective pooled analysis of data from 628,463 women. <i>International Journal of Cancer, 147</i>(5), 1306-1314.en_US
dc.identifier.cristinIDFRIDAID 1813679
dc.identifier.doi10.1002/ijc.32892
dc.identifier.issn0020-7136
dc.identifier.issn1097-0215
dc.identifier.urihttps://hdl.handle.net/10037/20221
dc.language.isoengen_US
dc.publisherWileyen_US
dc.relation.journalInternational Journal of Cancer
dc.relation.projectIDinfo:eu-repo/grantAgreement/RCN/?/?/?/?/?/en_US
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2020 The Author(s)en_US
dc.subjectVDP::Medical disciplines: 700::Health sciences: 800::Community medicine, Social medicine: 801en_US
dc.subjectVDP::Medisinske Fag: 700::Helsefag: 800::Samfunnsmedisin, sosialmedisin: 801en_US
dc.titleAdult weight change and premenopausal breast cancer risk: A prospective pooled analysis of data from 628,463 womenen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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