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dc.contributor.authorHarms, Laura
dc.contributor.authorScalbert, Augustin
dc.contributor.authorZamora-Ros, Raul
dc.contributor.authorRinaldi, Sabina
dc.contributor.authorJenab, Mazda
dc.contributor.authorMurphy, Neil
dc.contributor.authorAchaintre, David
dc.contributor.authorTjønneland, Anne
dc.contributor.authorOlsen, Anja
dc.contributor.authorOvervad, Kim
dc.contributor.authorRomana, Mancini
dc.contributor.authorMahamat-Saleh, Yahya
dc.contributor.authorBoutron-Ruault, Marie-Christine
dc.contributor.authorKühn, Tilman
dc.contributor.authorKatzke, Verena
dc.contributor.authorTrichopoulou, Antonia
dc.contributor.authorMartimianaki, Georgia
dc.contributor.authorKarakatsani, Anna
dc.contributor.authorPalli, Domenico
dc.contributor.authorPanico, Salvatore
dc.contributor.authorSieri, Sabina
dc.contributor.authorTumino, Rosario
dc.contributor.authorSacerdote, Carlotta
dc.contributor.authorBueno-de-Mesquita, Hendrik Bastian
dc.contributor.authorVermeulen, Roel
dc.contributor.authorWeiderpass, Elisabete
dc.contributor.authorNøst, Therese Haugdahl
dc.contributor.authorLasheras, Cristina
dc.contributor.authorRodrÍguez-Barranco, Miguel
dc.contributor.authorHuerta, José María
dc.contributor.authorBarricarte, Aurelio
dc.contributor.authorDorronsoro, Miren
dc.contributor.authorHultdin, Johan
dc.contributor.authorSchmidt, Julie A.
dc.contributor.authorGunter, Marc
dc.contributor.authorRiboli, Elio
dc.contributor.authorAleksandrova, Krasimira
dc.date.accessioned2021-01-11T12:40:30Z
dc.date.available2021-01-11T12:40:30Z
dc.date.issued2019-10-04
dc.description.abstractExperimental studies have reported on the anti-inflammatory properties of polyphenols. However, results from epidemiological investigations have been inconsistent and especially studies using biomarkers for assessment of polyphenol intake have been scant. We aimed to characterise the association between plasma concentrations of thirty-five polyphenol compounds and low-grade systemic inflammation state as measured by high-sensitivity C-reactive protein (hsCRP). A cross-sectional data analysis was performed based on 315 participants in the European Prospective Investigation into Cancer and Nutrition cohort with available measurements of plasma polyphenols and hsCRP. In logistic regression analysis, the OR and 95 % CI of elevated serum hsCRP (>3 mg/l) were calculated within quartiles and per standard deviation higher level of plasma polyphenol concentrations. In a multivariable-adjusted model, the sum of plasma concentrations of all polyphenols measured (per standard deviation) was associated with 29 (95 % CI 50, 1) % lower odds of elevated hsCRP. In the class of flavonoids, daidzein was inversely associated with elevated hsCRP (OR 0·66, 95 % CI 0·46, 0·96). Among phenolic acids, statistically significant associations were observed for 3,5-dihydroxyphenylpropionic acid (OR 0·58, 95 % CI 0·39, 0·86), 3,4-dihydroxyphenylpropionic acid (OR 0·63, 95 % CI 0·46, 0·87), ferulic acid (OR 0·65, 95 % CI 0·44, 0·96) and caffeic acid (OR 0·69, 95 % CI 0·51, 0·93). The odds of elevated hsCRP were significantly reduced for hydroxytyrosol (OR 0·67, 95 % CI 0·48, 0·93). The present study showed that polyphenol biomarkers are associated with lower odds of elevated hsCRP. Whether diet rich in bioactive polyphenol compounds could be an effective strategy to prevent or modulate deleterious health effects of inflammation should be addressed by further well-powered longitudinal studies.en_US
dc.identifier.citationHarms, L.M., Scalbert, A., Zamora-Ros, R., Rinaldi, S., Jenab, M., Murphy, N. ... Aleksandrova, K. (2019). Plasma polyphenols associated with lower high-sensitivity C-reactive protein concentrations: A cross-sectional study within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. <i>British Journal of Nutrition, 123</i>(2), 198-208.en_US
dc.identifier.cristinIDFRIDAID 1816443
dc.identifier.doi10.1017/S0007114519002538
dc.identifier.issn0007-1145
dc.identifier.issn1475-2662
dc.identifier.urihttps://hdl.handle.net/10037/20266
dc.language.isoengen_US
dc.publisherCambridge University Press (CUP)en_US
dc.relation.journalBritish Journal of Nutrition
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2020 The Author(s)en_US
dc.subjectVDP::Medical disciplines: 700::Health sciences: 800::Community medicine, Social medicine: 801en_US
dc.subjectVDP::Medisinske Fag: 700::Helsefag: 800::Samfunnsmedisin, sosialmedisin: 801en_US
dc.titlePlasma polyphenols associated with lower high-sensitivity C-reactive protein concentrations: A cross-sectional study within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohorten_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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