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dc.contributor.authorNestegard, Oddmund
dc.contributor.authorJohnsen, Kay-Martin
dc.contributor.authorSørbye, Sveinung
dc.contributor.authorHalvorsen, Fred-Arne
dc.contributor.authorTønnessen, Tor
dc.contributor.authorPaulssen, Eyvind Jakob
dc.contributor.authorMelby, Kjetil K.
dc.contributor.authorGoll, Rasmus
dc.contributor.authorFlorholmen, Jon
dc.date.accessioned2021-01-22T08:33:05Z
dc.date.available2021-01-22T08:33:05Z
dc.date.issued2020-09-23
dc.description.abstract<i>Background and aims</i> - Patients that have failed therapy for Helicobacter pylori (H. pylori) infection are incompletely characterized. The aim of this study was to characterize a H. pylori treatment resistant cohort compared to the cohorts of newly diagnosed, earlier eradicated and non-infected.<p> <p><i>Material and methods</i> - Patients were selected from routine referrals to the Endoscopy units at three different Norwegian hospitals. In all four cohorts, gastric biopsies were scored according to the Sydney classification, and symptoms according to the Gastrointestinal Symptom Rating Scale score, including sub-scores for upper gastrointestinal symptoms and functional bowel symptoms. Patients in the H. pylori resistant group were treated with a triple therapy regimen that consisted of levofloxacin, amoxicillin and a proton pump inhibitor.<p> <p><i>Results</i> - We included 185 patients, 42 H. pylori treatment resistant, 50 newly diagnosed, 61 previously H. pylori eradicated and 32 never infected. The treatment-resistant cohort had higher scores for upper gastrointestinal symptoms and functional bowel symptoms compared to the other groups except for the group being never H. pylori infected. The H. pylori resistant patients had lower Sydney scores than patients with newly diagnosed H. pylori infection. The triple combination showed a high efficacy of 91% to eradicate H. pylori.<p> <p><i>Conclusions</i> - Patients with treatment-resistant H. pylori infection had more gastrointestinal symptoms, but a lower Sydney score than patients with newly diagnosed infection. A treatment regimen including levofloxacin showed a high efficacy in eradicating H. pylori in patients that previously had failed eradication treatment.en_US
dc.identifier.citationNestegard O, Johnsen K, Sørbye SW, Halvorsen F, Tønnessen T, Paulssen EJ, Melby KK, Goll r, Florholmen J. Clinical characterization of Helicobacter pylori infected patients 15 years after unsuccessful eradication. PLOS ONE. 2020;15(9)
dc.identifier.cristinIDFRIDAID 1874013
dc.identifier.doi10.1371/journal.pone.0238944
dc.identifier.issn1932-6203
dc.identifier.urihttps://hdl.handle.net/10037/20377
dc.language.isoengen_US
dc.publisherPublic Library of Scienceen_US
dc.relation.journalPLOS ONE
dc.rights.holderCopyright 2020 The Author(s)en_US
dc.subjectVDP::Medical disciplines: 700::Basic medical, dental and veterinary science disciplines: 710en_US
dc.subjectVDP::Medisinske Fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710en_US
dc.titleClinical characterization of Helicobacter pylori infected patients 15 years after unsuccessful eradicationen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US


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