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dc.contributor.authorShrestha, Anup
dc.contributor.authorBruckmüller, Henrike
dc.contributor.authorKildalsen, Hanne
dc.contributor.authorKaur, Gurjit
dc.contributor.authorGaestel, Matthias
dc.contributor.authorLjones Wetting, Hilde
dc.contributor.authorMikkola, Ingvild
dc.contributor.authorSeternes, Ole Morten
dc.date.accessioned2021-01-23T12:31:34Z
dc.date.available2021-01-23T12:31:34Z
dc.date.issued2020-06-09
dc.description.abstractSteroid receptor coactivator-3 (SRC-3) regulates the activity of both nuclear hormone receptors and a number of key transcription factors. It is implicated in the regulation of cell proliferation, inflammation and in the progression of several common cancers including breast, colorectal and lung tumors. Phosphorylation is an important regulatory event controlling the activities of SRC-3. Serine 857 is the most studied phospho-acceptor site, and its modification has been reported to be important for SRC-3-dependent tumor progression. In this study, we show that the stress-responsive p38<sup>MAPK</sup>-MK2 signaling pathway controls the phosphorylation of SRC-3 at S857 in a wide range of human cancer cells. Activation of the p38<sup>MAPK</sup>-MK2 pathway results in the nuclear translocation of SRC-3, where it contributes to the transactivation of NF-kB and thus regulation of IL-6 transcription. The identification of the p38<sup>MAPK</sup>-MK2 signaling axis as a key regulator of SRC-3 phosphorylation and activity opens up new possibilities for the development and testing of novel therapeutic strategies to control both proliferative and metastatic tumor growth.en_US
dc.identifier.citationShrestha A, Bruckmüller H, Kildalsen h, Kaur, Gaestel M, Ljones Wetting H, Mikkola i, Seternes om. Phosphorylation of steroid receptor coactivator-3 (SRC-3) at serine 857 is regulated by the p38 MAPK-MK2 axis and affects NF-κB-mediated transcription . Scientific Reports. 2020en_US
dc.identifier.cristinIDFRIDAID 1837719
dc.identifier.doi10.1038/s41598-020-68219-4
dc.identifier.issn2045-2322
dc.identifier.urihttps://hdl.handle.net/10037/20411
dc.language.isoengen_US
dc.publisherSpringeren_US
dc.relation.ispartofShrestha, A. (2022). The Regulation of Steroid Receptor Co-activator-3 Activity by p38MAPK-MK2 Signaling Pathway. (Doctoral thesis). <a href=https://hdl.handle.net/10037/26873>https://hdl.handle.net/10037/26873</a>.
dc.relation.journalScientific Reports
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2020 The Author(s)en_US
dc.subjectVDP::Medical disciplines: 700::Basic medical, dental and veterinary science disciplines: 710::Pharmacology: 728en_US
dc.subjectVDP::Medisinske Fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710::Farmakologi: 728en_US
dc.titlePhosphorylation of steroid receptor coactivator-3 (SRC-3) at serine 857 is regulated by the p38 MAPK-MK2 axis and affects NF-κB-mediated transcriptionen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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