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dc.contributor.authorJørgensen, Marthe Jøntvedt
dc.contributor.authorHolter, Jan Cato
dc.contributor.authorChristensen, Erik
dc.contributor.authorSchjalm, Camilla
dc.contributor.authorTonby, Kristian
dc.contributor.authorPischke, Soeren
dc.contributor.authorJenum, Synne
dc.contributor.authorSkeie, Linda Gail
dc.contributor.authorNur, Sarah
dc.contributor.authorLind, Andreas
dc.contributor.authorOpsand, Hanne
dc.contributor.authorEnersen, Tone Burvald
dc.contributor.authorGrøndahl, Ragnhild
dc.contributor.authorHermann, Anne
dc.contributor.authorDudman, Susanne Gjeruldsen
dc.contributor.authorMüller, Fredrik
dc.contributor.authorUeland, Thor
dc.contributor.authorMollnes, Tom Eirik
dc.contributor.authorAukrust, Pål
dc.contributor.authorHeggelund, Lars
dc.contributor.authorHolten, Aleksander Rygh
dc.contributor.authorDyrhol-Riise, Anne Ma
dc.date.accessioned2021-01-23T13:03:34Z
dc.date.available2021-01-23T13:03:34Z
dc.date.issued2020-12-10
dc.description.abstractIn SARS-CoV-2 infection there is an urgent need to identify patients that will progress to severe COVID-19 and may benefit from targeted treatment. In this study we analyzed plasma cytokines in COVID-19 patients and investigated their association with respiratory failure (RF) and treatment in Intensive Care Unit (ICU). Hospitalized patients (n = 34) with confirmed COVID-19 were recruited into a prospective cohort study. Clinical data and blood samples were collected at inclusion and after 2–5 and 7–10 days. RF was defined as PaO2/FiO2 ratio (P/F) < 40 kPa. Plasma cytokines were analyzed by a Human Cytokine 27-plex assay. COVID-19 patients with RF and/or treated in ICU showed overall increased systemic cytokine levels. Plasma IL-6, IL-8, G-CSF, MCP-1, MIP-1α levels were negatively correlated with P/F, whereas combinations of IL-6, IP-10, IL-1ra and MCP-1 showed the best association with RF in ROC analysis (AUC 0.79–0.80, p < 0.05). During hospitalization the decline was most significant for IP-10 (p < 0.001). Elevated levels of pro-inflammatory cytokines were present in patients with severe COVID-19. IL-6 and MCP-1 were inversely correlated with P/F with the largest AUC in ROC analyses and should be further explored as biomarkers to identify patients at risk for severe RF and as targets for improved treatment strategies.en_US
dc.identifier.citationJørgensen, Holter, Christensen E, Schjalm, Tonby, Pischke, Jenum, Skeie, Nur, Lind, Opsand, Enersen, Grøndahl, Hermann, Dudman, Müller, Ueland, Mollnes, Aukrust, Heggelund, Holten, Dyrhol-Riise. Increased interleukin-6 and macrophage chemoattractant protein-1 are associated with respiratory failure in COVID-19. Scientific Reports. 2020;10:21697:1-11en_US
dc.identifier.cristinIDFRIDAID 1865525
dc.identifier.doi10.1038/s41598-020-78710-7
dc.identifier.issn2045-2322
dc.identifier.urihttps://hdl.handle.net/10037/20416
dc.language.isoengen_US
dc.publisherSpringeren_US
dc.relation.journalScientific Reports
dc.relation.projectIDinfo:eu-repo/grantAgreement/RCN/?/ 312780?/Norway/?/?/en_US
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2020 The Author(s)en_US
dc.subjectVDP::Medical disciplines: 700::Basic medical, dental and veterinary science disciplines: 710en_US
dc.subjectVDP::Medisinske Fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710en_US
dc.titleIncreased interleukin-6 and macrophage chemoattractant protein-1 are associated with respiratory failure in COVID-19en_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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