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dc.contributor.authorLudden, Catherine
dc.contributor.authorLötsch, Felix
dc.contributor.authorAlm, Erik
dc.contributor.authorKumar, Narender
dc.contributor.authorJohansson, Karin
dc.contributor.authorAlbiger, Barbara
dc.contributor.authorHuang, Te-Din
dc.contributor.authorDenis, Olivier
dc.contributor.authorHammerum, Anette M.
dc.contributor.authorHasman, Henrik
dc.contributor.authorJalava, Jari
dc.contributor.authorRäisänen, Kati
dc.contributor.authorDortet, Laurent
dc.contributor.authorJousset, Agnès B.
dc.contributor.authorGatermann, Sören
dc.contributor.authorHaller, Sebastian
dc.contributor.authorCormican, Martin
dc.contributor.authorBrennan, Wendy
dc.contributor.authorGrosso, Maria Del
dc.contributor.authorMonaco, Monica
dc.contributor.authorSchouls, Leo
dc.contributor.authorSamuelsen, Ørjan
dc.contributor.authorPirš, Mateja
dc.contributor.authorCerar, Tjaša
dc.contributor.authorOteo-Iglesias, Jésus
dc.contributor.authorPérez-Vázquez, Maria
dc.contributor.authorSjöström, Karin
dc.contributor.authorEdquist, Petra
dc.contributor.authorHopkins, Katie L.
dc.contributor.authorStruelens, Marc J.
dc.contributor.authorPalm, Daniel
dc.contributor.authorMonnet, Dominique L.
dc.contributor.authorKohlenberg, Anke
dc.date.accessioned2021-02-08T11:55:14Z
dc.date.available2021-02-08T11:55:14Z
dc.date.issued2020-05-21
dc.description.abstractAn alert regarding an outbreak of carbapenem-resistant <i>Klebsiella pneumoniae</i> carrying <i>bla</i> <sub>NDM-1</sub> and <i>bla</i> <sub>OXA-48</sub> carbapenemase-encoding genes was sent by Germany to European Union (EU)/European Economic Area (EEA) countries in October 2019. Since only limited whole genome sequencing (WGS) data on <i>bla</i> <sub>NDM-1-</sub> and <i>bla</i> <sub>OXA-48</sub>-positive <i>K. pneumoniae</i> were available in the public domain, national public health reference or equivalent expert laboratories from EU/EEA countries were invited to share WGS data from their national collections with the European Centre for Disease Prevention and Control (ECDC) to investigate the international dissemination of this epidemic strain. The analysis identified a Finnish case with an isolate closely related to the German outbreak strain and with an epidemiological link to St. Petersburg, Russia. In addition, several other clusters of genetically related <i>bla</i> <sub>NDM-1-</sub> and <i>bla</i> <sub>OXA-48</sub>-positive <i>K. pneumoniae</i> unrelated to the German outbreak strain but affecting numerous EU/EEA countries were identified. The aim of this follow-up investigation was to characterise these clusters based on the integrated analysis of the WGS dataset on <i>bla</i> <sub>NDM-1</sub> - and <i>bla</i> <sub>OXA-48</sub>-positive <i>K. pneumoniae</i> submitted from 13 EU/EEA countries and additional epidemiological data.en_US
dc.identifier.citationLudden, Lötsch, Alm, Kumar, Johansson, Albiger, Huang, Denis, Hammerum, Hasman, Jalava, Räisänen, Dortet, Jousset, Gatermann, Haller, Cormican, Brennan, Grosso, Monaco, Schouls, Samuelsen, Pirš, Cerar, Oteo-Iglesias, Pérez-Vázquez, Sjöström, Edquist, Hopkins, Struelens, Palm, Monnet, Kohlenberg. Cross-border spread of blaNDM-1- and blaOXA-48-positive Klebsiella pneumoniae: a European collaborative analysis of whole genome sequencing and epidemiological data, 2014 to 2019. Eurosurveillance. 2020;25(20)en_US
dc.identifier.cristinIDFRIDAID 1849496
dc.identifier.doi10.2807/1560-7917.ES.2020.25.20.2000627
dc.identifier.issn1025-496X
dc.identifier.issn1560-7917
dc.identifier.urihttps://hdl.handle.net/10037/20532
dc.language.isoengen_US
dc.publisherEuropean Centre for Disease Prevention and Control (ECDC)en_US
dc.relation.journalEurosurveillance
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2020 The Author(s)en_US
dc.subjectVDP::Medical disciplines: 700::Clinical medical disciplines: 750::Lung diseases: 777en_US
dc.subjectVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Lungesykdommer: 777en_US
dc.titleCross-border spread of blaNDM-1- and blaOXA-48-positive Klebsiella pneumoniae: a European collaborative analysis of whole genome sequencing and epidemiological data, 2014 to 2019en_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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