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dc.contributor.authorUrbani, Lorenza
dc.contributor.authorTryland, Morten
dc.contributor.authorEhrich, Dorothee
dc.contributor.authorFuglei, Eva
dc.contributor.authorBattilani, Mara
dc.contributor.authorBalboni, Andrea
dc.date.accessioned2021-03-01T09:28:32Z
dc.date.available2021-03-01T09:28:32Z
dc.date.issued2020-08-12
dc.description.abstractCanine circovirus (CanineCV) is a relatively new viral species, belonging to the family <i>Circoviridae</i>, whose pathogenic role is still uncertain. Since its first description in one domestic dog in 2011 from the USA, several reports have been documenting its distribution worldwide. Recently, CanineCV was also detected in wild animals such as wolves, foxes and badgers. In order to investigate the presence and the genetic characteristics of CanineCV in foxes of Arctic and Sub‐Arctic regions, the presence of CanineCV DNA in internal organs (liver and spleen) of 51 arctic foxes (<i>Vulpes lagopus</i>) from Svalbard archipelago and 59 red foxes (<i>Vulpes vulpes</i>) from Northern Norway, sampled from 1996 to 2001 and from 2014 to 2018, respectively, was screened by real‐time PCR. CanineCV was detected in 11/51 arctic foxes and in 10/59 red foxes, backdating the circulation of the virus at least to 1996 in the arctic fox population. The complete genome of 14 identified CanineCV was sequenced and analysed showing an identity higher than 80.8% with the reference strains available to date. According to the species demarcation threshold of 80% genome‐wide nucleotide sequence identity for members of the family <i>Circoviridae</i> provided by International Committee on Taxonomy of Viruses (ICTV), all the CanineCV belong to a single species. Phylogenetic analysis revealed that all the CanineCV were subdivided into five main clusters with one including only CanineCV identified in foxes. Furthermore, CanineCV identified in arctic foxes and red foxes formed two distinct lineages. From these data, we hypothesize that the viral transmission did not occur between the two species of foxes as a consequence of the lack of contact between the two hosts or that the virus acquired mutations in the time elapsed between the samplings.en_US
dc.descriptionThis is the pre-peer reviewed version of the following article: Urbani, Tryland, Ehrich, Fuglei, Battilani, Balboni. Ancient origin and genetic segregation of canine circovirus infecting arctic foxes (Vulpes lagopus) in Svalbard and red foxes (Vulpes vulpes) in Northern Norway. Transboundary and Emerging Diseases. 2020;00:1-11, which has been published in final form at <a href=https://doi.org/10.1111/tbed.13783>https://doi.org/10.1111/tbed.13783. </a> This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.en_US
dc.identifier.citationUrbani, Tryland, Ehrich, Fuglei, Battilani, Balboni. Ancient origin and genetic segregation of canine circovirus infecting arctic foxes (Vulpes lagopus) in Svalbard and red foxes (Vulpes vulpes) in Northern Norway. Transboundary and Emerging Diseases. 2020;00:1-11en_US
dc.identifier.cristinIDFRIDAID 1843560
dc.identifier.doi10.1111/tbed.13783
dc.identifier.issn1865-1674
dc.identifier.issn1865-1682
dc.identifier.urihttps://hdl.handle.net/10037/20615
dc.language.isoengen_US
dc.publisherWileyen_US
dc.relation.journalTransboundary and Emerging Diseases
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2020 The Author(s)en_US
dc.subjectVDP::Mathematics and natural science: 400::Zoology and botany: 480en_US
dc.subjectVDP::Matematikk og Naturvitenskap: 400::Zoologiske og botaniske fag: 480en_US
dc.titleAncient origin and genetic segregation of canine circovirus infecting arctic foxes (Vulpes lagopus) in Svalbard and red foxes (Vulpes vulpes) in Northern Norwayen_US
dc.type.versionacceptedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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