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Evaluation of the performance of clinical predictors in estimating the probability of pulmonary tuberculosis among smear-negative cases in Northern Ethiopia: A cross-sectional study

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https://hdl.handle.net/10037/20666
DOI
https://doi.org/10.1136/bmjopen-2020-037913
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Date
2020-11-03
Type
Journal article
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Author
George, Mala; Dinant, Geert-Jan; Kentiba, Efrem; Teshome, Teklu; Teshome, Abinet; Tsegaye, Behailu; Spigt, Mark
Abstract
Objectives - To evaluate the performance of the predictors in estimating the probability of pulmonary tuberculosis (PTB) when all versus only significant variables are combined into a decision model (1) among all clinical suspects and (2) among smear-negative cases based on the results of culture tests.

Design - A cross-sectional study.

Setting - Two public referral hospitals in Tigray, Ethiopia.

Participants - A total of 426 consecutive adult patients admitted to the hospitals with clinical suspicion of PTB were screened by sputum smear microscopy and chest radiograph (chest X-ray (CXR)) in accordance with the Ethiopian guidelines of the National Tuberculosis and Leprosy Program. Discontinuation of antituberculosis therapy in the past 3 months, unproductive cough, HIV positivity and unwillingness to give written informed consent were the basis of exclusion from the study.

Primary and secondary outcome measures - A total of 354 patients were included in the final analysis, while 72 patients were excluded because culture tests were not done.

Results - The strongest predictive variables of culture-positive PTB among patients with clinical suspicion were a positive smear test (OR 172; 95% CI 23.23 to 1273.54) and having CXR lesions compatible with PTB (OR 10.401; 95% CI 5.862 to 18.454). The regression model had a good predictive performance for identifying culture-positive PTB among patients with clinical suspicion (area under the curve (AUC) 0.84), but it was rather poor in patients with a negative smear result (AUC 0.64). Combining all the predictors in the model compared with only the independent significant variables did not really improve its performance to identify culture-positive (AUC 0.84–0.87) and culture-negative (AUC 0.64–0.69) PTB.

Conclusions - Our finding suggests that predictive models based on clinical variables will not be useful to discriminate patients with culture-negative PTB from patients with culture-positive PTB among patients with smear-negative cases.

Citation
George, Dinant, Kentiba, Teshome, Teshome, Tsegaye, Spigt. Evaluation of the performance of clinical predictors in estimating the probability of pulmonary tuberculosis among smear-negative cases in Northern Ethiopia: A cross-sectional study. BMJ Open. 2020;10(11):1-9
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