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dc.contributor.authorRiaz, Misbah
dc.contributor.authorVangberg, Torgil Riise
dc.contributor.authorVasylenko, Olena
dc.contributor.authorCastro Chavira, Susana Angelica
dc.contributor.authorGorecka, Marta Maria
dc.contributor.authorWaterloo, Knut
dc.contributor.authorRodriguez-Aranda, Claudia
dc.date.accessioned2021-03-22T07:47:21Z
dc.date.available2021-03-22T07:47:21Z
dc.date.issued2020-08-29
dc.description.abstract<i>Background</i> - White matter hyperintensities (WMH) are a common cerebral finding in older people. WMH are usually asymptomatic, but excessive WMH are associated with cognitive decline and dementia. WMH are also among the neurological findings most consistently associated with declining motor performance in healthy ageing.<br><br> <i>Aims</i> - To determine if WMH load is associated with simple and complex motor movements in dominant and non-dominant hands in cognitively intact older subjects.<br><br> <i>Methods</i> - Hand motor performance was assessed with the Purdue Pegboard and Finger-tapping tests on 44 healthy right-handed participants, mean age 70.9 years (range 59–84 years). Participants also underwent magnetic resonance (MR) imaging, which were used to quantify WMH volume. The effect of WMH on the motor parameters was assessed via mediation analyses.<br><br> <i>Results</i> - WMH load increased significantly with age, while the motor scores decreased significantly with age. WMH load mediated only the relationship between age and left-hand pegboard scores.<br><br> <i>Discussion</i> - WMH mediated only the more complex Purdue Pegboard task for the non-dominant hand. This is likely because complex movements in the non-dominant hand recruit a larger cerebral network, which is more vulnerable to WMH.<br><br> <i>Conclusions</i> - Complex hand movements in the non-dominant hand are mediated by WMH. Subtle loss of motor movements of non-dominant hand might predict future excessive white matter atrophy.en_US
dc.identifier.citationRiaz, Vangberg TR, Vasylenko O, Castro Chavira SA, Gorecka MM, Waterloo K, Rodriguez-Aranda Cra. What does hand motor function tell us about our aging brain in association with WMH?. Aging Clinical and Experimental Research. 2020en_US
dc.identifier.cristinIDFRIDAID 1836543
dc.identifier.doi10.1007/s40520-020-01683-0
dc.identifier.issn1594-0667
dc.identifier.issn1720-8319
dc.identifier.urihttps://hdl.handle.net/10037/20706
dc.language.isoengen_US
dc.publisherSpringeren_US
dc.relation.journalAging Clinical and Experimental Research
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2020 The Author(s)en_US
dc.subjectVDP::Medical disciplines: 700en_US
dc.subjectVDP::Medisinske Fag: 700en_US
dc.titleWhat does hand motor function tell us about our aging brain in association with WMH?en_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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