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dc.contributor.authorPerez-Cornago, Aurora
dc.contributor.authorCrowe, Francesca L
dc.contributor.authorAppleby, Paul N
dc.contributor.authorBradbury, Kathryn E
dc.contributor.authorWood, Angela M.
dc.contributor.authorJakobsen, Marianne Uhre
dc.contributor.authorJohnson, Laura
dc.contributor.authorSacerdote, Carlotta
dc.contributor.authorSteur, Marinka
dc.contributor.authorWeiderpass, Elisabete
dc.contributor.authorWürtz, Anne Mette L
dc.contributor.authorKühn, Tilman
dc.contributor.authorKatzke, Verena
dc.contributor.authorTrichopoulou, Antonia
dc.contributor.authorKarakatsani, Anna
dc.contributor.authorVecchia, Carlo La
dc.contributor.authorMasala, Giovanna
dc.contributor.authorTumino, Rosario
dc.contributor.authorPanico, Salvatore
dc.contributor.authorSluijs, Ivonne
dc.contributor.authorSkeie, Guri
dc.contributor.authorImaz, Liher
dc.contributor.authorPetrova, Dafina
dc.contributor.authorRamón Quirós, J
dc.contributor.authorYohar, Sandra Milena Colorado
dc.contributor.authorJakszyn, Paula
dc.contributor.authorMelander, Olle
dc.contributor.authorSonestedt, Emily
dc.contributor.authorAndersson, Jonas
dc.contributor.authorWennberg, Maria
dc.contributor.authorAune, Dagfinn
dc.contributor.authorRiboli, Elio
dc.contributor.authorSchulze, Matthias B
dc.contributor.authordi Angelantonio, Emanuele
dc.contributor.authorWareham, Nicholas J
dc.contributor.authorDanesh, John
dc.contributor.authorForouhi, Nita G
dc.contributor.authorButterworth, Adam S
dc.contributor.authorKey, Timothy J
dc.date.accessioned2021-04-07T11:47:33Z
dc.date.available2021-04-07T11:47:33Z
dc.date.issued2020-11-27
dc.description.abstract<i>Background</i> - Epidemiological evidence indicates that diets rich in plant foods are associated with a lower risk of ischaemic heart disease (IHD), but there is sparse information on fruit and vegetable subtypes and sources of dietary fibre. This study examined the associations of major plant foods, their subtypes and dietary fibre with risk of IHD in the European Prospective Investigation into Cancer and Nutrition (EPIC).<p> <p><i>Methods</i> - We conducted a prospective analysis of 490 311 men and women without a history of myocardial infarction or stroke at recruitment (12.6 years of follow-up, <i>n</i> cases = 8504), in 10 European countries. Dietary intake was assessed using validated questionnaires, calibrated with 24-h recalls. Multivariable Cox regressions were used to estimate hazard ratios (HR) of IHD.<p> <p><i>Results</i> - There was a lower risk of IHD with a higher intake of fruit and vegetables combined [HR per 200 g/day higher intake 0.94, 95% confidence interval (CI): 0.90–0.99, <i>P</i>-trend = 0.009], and with total fruits (per 100 g/day 0.97, 0.95–1.00, <i>P</i>-trend = 0.021). There was no evidence for a reduced risk for fruit subtypes, except for bananas. Risk was lower with higher intakes of nuts and seeds (per 10 g/day 0.90, 0.82–0.98, <i>P</i>-trend = 0.020), total fibre (per 10 g/day 0.91, 0.85–0.98, <i>P</i>-trend = 0.015), fruit and vegetable fibre (per 4 g/day 0.95, 0.91–0.99, <i>P</i>-trend = 0.022) and fruit fibre (per 2 g/day 0.97, 0.95–1.00, <i>P</i>-trend = 0.045). No associations were observed between vegetables, vegetables subtypes, legumes, cereals and IHD risk.<p> <p><i>Conclusions</i> - In this large prospective study, we found some small inverse associations between plant foods and IHD risk, with fruit and vegetables combined being the most strongly inversely associated with risk. Whether these small associations are causal remains unclear.en_US
dc.identifier.citationPerez-Cornago, Crowe, Appleby, Bradbury, Wood, Jakobsen, Johnson, Sacerdote, Steur, Weiderpass, Würtz, Kühn, Katzke, Trichopoulou, Karakatsani, Vecchia, Masala, Tumino, Panico, Sluijs, Skeie, Imaz, Petrova, Ramón Quirós, Yohar, Jakszyn, Melander, Sonestedt, Andersson, Wennberg, Aune, Riboli, Schulze, di Angelantonio, Wareham, Danesh, Forouhi, Butterworth, Key. Plant foods, dietary fibre and risk of ischaemic heart disease in the European prospective investigation into cancer and nutrition (EPIC) cohort. International Journal of Epidemiology. 2020en_US
dc.identifier.cristinIDFRIDAID 1894242
dc.identifier.doi10.1093/ije/dyaa155
dc.identifier.issn0300-5771
dc.identifier.issn1464-3685
dc.identifier.urihttps://hdl.handle.net/10037/20793
dc.language.isoengen_US
dc.publisherOxford University Pressen_US
dc.relation.journalInternational Journal of Epidemiology
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/EPICHEART/268834/UnitedKingdom/Interplay of genetic, nutrient and lifestyle factors on incidence of coronary disease: EPIC-Heart//en_US
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/INTERACT/37197/UnitedKingdom/An examination of the interaction of genetic and lifestyle factors on the incidence of type 2 diabetes//en_US
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2020 The Author(s)en_US
dc.subjectVDP::Medical disciplines: 700::Health sciences: 800::Community medicine, Social medicine: 801en_US
dc.subjectVDP::Medisinske Fag: 700::Helsefag: 800::Samfunnsmedisin, sosialmedisin: 801en_US
dc.titlePlant foods, dietary fibre and risk of ischaemic heart disease in the European prospective investigation into cancer and nutrition (EPIC) cohorten_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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