dc.contributor.author | Grinde, Bjørn | |
dc.contributor.author | Schirmer, Henrik | |
dc.contributor.author | Eggen, Anne Elise | |
dc.contributor.author | Aigner, Ludwig | |
dc.contributor.author | Engdahl, Bo Lars | |
dc.date.accessioned | 2021-04-14T08:52:38Z | |
dc.date.available | 2021-04-14T08:52:38Z | |
dc.date.issued | 2020-10-09 | |
dc.description.abstract | Background - The leukotriene receptor antagonist montelukast has been shown to rejuvenate aged brains in rats; however, data on humans are still scarce. Objective To investigate if montelukast may alleviate degenerative neurological changes using a register data. Setting Norwegian registry data analyses. <p>
<p>Method - The present observational study was based on data from the Norwegian Prescription Database and the Tromsø Study. The former has information regarding the use of prescription medicine; the latter includes tests for brain function such as subjective memory and finger-tapping. Multivariate linear regression analyses were performed to see how the use of various medications correlated with the test results, correcting for likely confounders. <p>
<p>Main outcome measure - Results on seven different tests considered relevant for neurological health were used as outcome. Results Previous use of montelukast correlated with improved scores on cognitive or neurological functioning (F = 2.20, p = 0.03 in a multivariate test). A range of other medications were tested with the same algorithm, including drugs acting on the immune system, but none of them correlated with (overall) significantly improved test results. <p>
<p>Conclusion - The present data suggest that montelukast may alleviate degenerative neurological changes associated with human aging. | en_US |
dc.identifier.citation | Grinde B, Schirmer H, Eggen AE, Aigner L, Engdahl B.
A possible effect of montelukast on neurological aging examined by the use of register data. International Journal of Clinical Pharmacy. 2020 | en_US |
dc.identifier.cristinID | FRIDAID 1873478 | |
dc.identifier.doi | 10.1007/s11096-020-01160-8 | |
dc.identifier.issn | 2210-7703 | |
dc.identifier.issn | 2210-7711 | |
dc.identifier.uri | https://hdl.handle.net/10037/20866 | |
dc.language.iso | eng | en_US |
dc.publisher | Springer | en_US |
dc.relation.journal | International Journal of Clinical Pharmacy | |
dc.rights.accessRights | openAccess | en_US |
dc.rights.holder | Copyright 2020 The Author(s) | en_US |
dc.subject | VDP::Medical disciplines: 700::Health sciences: 800::Community medicine, Social medicine: 801 | en_US |
dc.subject | VDP::Medisinske Fag: 700::Helsefag: 800::Samfunnsmedisin, sosialmedisin: 801 | en_US |
dc.title | A possible effect of montelukast on neurological aging examined by the use of register data | en_US |
dc.type.version | publishedVersion | en_US |
dc.type | Journal article | en_US |
dc.type | Tidsskriftartikkel | en_US |
dc.type | Peer reviewed | en_US |