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dc.contributor.authorRinde, Fridtjof Balteskard
dc.contributor.authorFrønæs, Synne Grønvold
dc.contributor.authorGhanima, Waleed Khalid
dc.contributor.authorVik, Anders
dc.contributor.authorHansen, John-Bjarne
dc.contributor.authorBrækkan, Sigrid
dc.date.accessioned2021-04-15T12:16:40Z
dc.date.available2021-04-15T12:16:40Z
dc.date.issued2020-04-25
dc.description.abstractBackground - Current guidelines recommend the use of clinical decision rules, such as Wells score, in combination with D-dimer to assess the need for objective imaging to rule out deep vein thrombosis (DVT). However, the clinical decision rule has limitations, and use of D-dimer as a stand-alone test has been suggested.<p> <p>Objective - We aimed to assess the safety and efficiency of D-dimer as a stand-alone test to rule out DVT in outpatients referred with suspected DVT.<p> <p>Methods - We collected data from consecutive outpatients referred to our hospital with suspected DVT in 2008–2018. D-dimer levels were analyzed using STA® Liatest® D-Di assay. D-dimer as a stand-alone test was theoretically applied in retrospect, and the number of misdiagnosed events were estimated as if such an approach had been initially used. All patients were followed for three months.<p> <p>Results - Of 1765 included patients, 293 (16.6%) were diagnosed with DVT. A total of 491 patients (27.8%) had a negative D-dimer (<500 ng/mL). Of these, nine were diagnosed with DVT, yielding a failure rate for D-dimer as a stand-alone test of 1.8% (95% CI 0.8%–3.5%). The majority of the misdiagnosed patients had distal DVT. In analyses restricted to proximal DVTs, the failure rate was 0.6% (95% CI 0.1%–1.8%). D-dimer as a stand-alone approach reduced the proportion of required ultrasounds from 81.8% to 72.2%.<p> <p>Conclusion - D-dimer as a stand-alone test may be safe for excluding proximal DVT and reduce the proportion of required ultrasounds. Prospective management studies are needed to confirm our findings.
dc.descriptionSubmitted manuscript version
dc.identifier.citationRinde, Frønæs, Ghanima, Vik, Hansen, Brækkan. D-dimer as a stand-alone test to rule out deep vein thrombosis. Thrombosis Research. 2020;191:134-139
dc.identifier.cristinIDFRIDAID 1820494
dc.identifier.doi10.1016/j.thromres.2020.04.026
dc.identifier.issn0049-3848
dc.identifier.issn1879-2472
dc.identifier.urihttps://hdl.handle.net/10037/20889
dc.language.isoeng
dc.publisherElsevier
dc.relation.ispartofRinde, F.B. (2023). D-dimer for diagnosis and risk assessment of first and recurrent venous thromboembolism. (Doctoral thesis). <a href=https://hdl.handle.net/10037/29270>https://hdl.handle.net/10037/29270</a>.
dc.relation.journalThrombosis Research
dc.rights.holderCopyright 2020 The Author(s)
dc.titleD-dimer as a stand-alone test to rule out deep vein thrombosis
dc.typeJournal article
dc.typeTidsskriftartikkel


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