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dc.contributor.authorHald, Erin Mathiesen
dc.contributor.authorLøchen, Maja-Lisa
dc.contributor.authorMathiesen, Ellisiv B
dc.contributor.authorWilsgaard, Tom
dc.contributor.authorNjølstad, Inger
dc.contributor.authorBrækkan, Sigrid K.
dc.contributor.authorHansen, John-Bjarne
dc.date.accessioned2021-04-15T12:32:01Z
dc.date.available2021-04-15T12:32:01Z
dc.date.issued2020-07-06
dc.description.abstractBackground Atrial fibrillation (AF) is associated with increased risk of ischemic stroke and all‐cause mortality. Patients with AF are also at increased risk of venous thromboembolism (VTE), but information on how AF impacts VTE‐related mortality is scarce. Objectives - To investigate the impact of AF on all‐cause mortality in subjects with and without a thromboembolic event (VTE or ischemic stroke).<p> <p>Methods - We followed 29 833 participants from the Tromsø study (1994‐2008) through 2013 and recorded all deaths during follow‐up. Incident AF, VTE, and ischemic stroke were registered as time‐dependent exposures. We calculated mortality rates (MRs) by exposure during follow‐up and obtained hazard ratios (HRs) for death with 95% confidence intervals (CIs).<p> <p>Results - A total of 2087 AF cases, 756 VTEs, and 1279 ischemic strokes were registered during a median follow‐up of 18.7 years, and 4797 people (16.1%) died. The age‐adjusted MR for participants without any event was 1.19 per 100 person‐years (PY; 95% CI, 1.15‐1.23). Compared to these participants, subjects with the joint AF + VTE exposure had a 3.7‐fold increased risk of death (HR, 3.67; 95% CI, 2.77‐4.66) in age‐ and sex‐adjusted analyses, similar to the risk observed for VTE alone (HR, 3.76; 95% CI, 3.28‐4.30). Participants with stroke had a 2.9‐fold increased risk of death (HR, 2.85; 95% CI, 2.56‐3.18), and the risk was further increased in participants with both AF and stroke (HR, 4.38; 95% CI, 3.85‐4.98).<p> <p>Conclusions - AF was significantly associated with increased risk of death in participants with incident stroke. In contrast, concomitant AF was not associated with excess mortality risk in VTE patients.en_US
dc.identifier.citationHald EM, Løchen M, Mathiesen EB, Wilsgaard T, Njølstad I, Brækkan SK, Hansen J. Atrial fibrillation, venous thromboembolism, ischemic stroke, and all-cause mortality: The Tromsø study. Research and Practice in Thrombosis and Haemostasis. 2020;4(6):1004-1012en_US
dc.identifier.cristinIDFRIDAID 1875444
dc.identifier.doi10.1002/rth2.12351
dc.identifier.issn2475-0379
dc.identifier.urihttps://hdl.handle.net/10037/20890
dc.language.isoengen_US
dc.publisherWileyen_US
dc.relation.journalResearch and Practice in Thrombosis and Haemostasis
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2020 The Author(s)en_US
dc.subjectVDP::Medical disciplines: 700::Basic medical, dental and veterinary science disciplines: 710en_US
dc.subjectVDP::Medisinske Fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710en_US
dc.titleAtrial fibrillation, venous thromboembolism, ischemic stroke, and all-cause mortality: The Tromsø studyen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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