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dc.contributor.authorToussaint, Magali
dc.contributor.authorDeuther-Conrad, Winnie
dc.contributor.authorKranz, Mathias
dc.contributor.authorFischer, Steffen
dc.contributor.authorLudwig, Friedrich-Alexander
dc.contributor.authorJuratli, Tareq A.
dc.contributor.authorPatt, Marianne
dc.contributor.authorWünsch, Bernhard
dc.contributor.authorSchackert, Gabriele
dc.contributor.authorSabri, Osama
dc.contributor.authorBrust, Peter
dc.date.accessioned2021-04-27T11:11:51Z
dc.date.available2021-04-27T11:11:51Z
dc.date.issued2020-05-06
dc.description.abstractGlioblastoma multiforme (GBM) is the most devastating primary brain tumour characterised by infiltrative growth and resistance to therapies. According to recent research, the sigma-1 receptor (sig1R), an endoplasmic reticulum chaperone protein, is involved in signaling pathways assumed to control the proliferation of cancer cells and thus could serve as candidate for molecular characterisation of GBM. To test this hypothesis, we used the clinically applied sig1R-ligand (S)-(−)-[<sup>18</sup>F]fluspidine in imaging studies in an orthotopic mouse model of GBM (U87-MG) as well as in human GBM tissue. A tumour-specific overexpression of sig1R in the U87-MG model was revealed in vitro by autoradiography. The binding parameters demonstrated target-selective binding according to identical K<sub>D</sub> values in the tumour area and the contralateral side, but a higher density of sig1R in the tumour. Different kinetic profiles were observed in both areas, with a slower washout in the tumour tissue compared to the contralateral side. The translational relevance of sig1R imaging in oncology is reflected by the autoradiographic detection of tumour-specific expression of sig1R in samples obtained from patients with glioblastoma. Thus, the herein presented data support further research on sig1R in neuro-oncology.en_US
dc.identifier.citationToussaint, Deuther-Conrad, Kranz, Fischer, Ludwig, Juratli, Patt, Wünsch, Schackert, Sabri, Brust. Sigma-1 receptor positron emission tomography: A new molecular imaging approach using (S)-(-)-[18F]fluspidine in glioblastoma. Molecules. 2020;25:2170(9):1-17en_US
dc.identifier.cristinIDFRIDAID 1891420
dc.identifier.doi10.3390/molecules25092170
dc.identifier.issn1420-3049
dc.identifier.urihttps://hdl.handle.net/10037/21074
dc.language.isoengen_US
dc.publisherMDPIen_US
dc.relation.journalMolecules
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2020 The Author(s)en_US
dc.subjectVDP::Medical disciplines: 700::Basic medical, dental and veterinary science disciplines: 710en_US
dc.subjectVDP::Medisinske Fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710en_US
dc.titleSigma-1 receptor positron emission tomography: A new molecular imaging approach using (S)-(-)-[18F]fluspidine in glioblastomaen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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