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dc.contributor.authorLipcsey, Miklos
dc.contributor.authorTenhunen, Jyrki
dc.contributor.authorPischke, Soeren
dc.contributor.authorKuitunen, Anne
dc.contributor.authorFlaatten, Hans
dc.contributor.authorDe Geer, Lina
dc.contributor.authorSjölin, Jan
dc.contributor.authorFrithiof, Robert
dc.contributor.authorChew, Michelle S.
dc.contributor.authorBendel, Stepani
dc.contributor.authorKawati, Rafael
dc.contributor.authorLarsson, Anders
dc.contributor.authorMollnes, Tom Eirik
dc.contributor.authorTønnessen, Tor Inge
dc.contributor.authorRubertsson, Sten
dc.date.accessioned2021-05-10T09:42:44Z
dc.date.available2021-05-10T09:42:44Z
dc.date.issued2020-08
dc.description.abstract<i>Purpose</i>: Lipopolysaccharides (LPS) are presumed to contribute to the inflammatory response in sepsis. We investigated if extracorporeal Alteco LPS Adsorber for LPS removal in early gram-negative septic shock was feasible and safe. Also, effects on endotoxin level, inflammatory response, and organ function were assessed.<br><br> <i>Methods</i>: A pilot, double-blinded, randomized, Phase IIa, feasibility clinical investigation was undertaken in six Scandinavian intensive care units aiming to allocate 32 septic shock patients with abdominal or urogenital focus on LPS Adsorber therapy or a Sham Adsorber, therapy without active LPS binding. The study treatment was initiated within 12 h of inclusion and given for 6 h daily on first 2 days. LPS was measured in all patients.<br><br> <i>Results</i>: The investigation was terminated after 527 days with eight patients included in the LPS Adsorber group and seven in the Sham group. Twenty-one adverse effects, judged not to be related to the device, were reported in three patients in the LPS Adsorber group and two in the Sham group. Two patients in the Sham group and no patients in the LPS Adsorber group died within 28 days. Plasma LPS levels were low without groups differences during or after adsorber therapy. The changes in inflammatory markers and organ function were similar in the groups.<br><br> <i>Conclusions</i>: In a small cohort of patients with presumed gram-negative septic shock, levels of circulating endotoxin were low and no adverse effects within 28 days after LPS adsorber-treatment were observed. No benefit compared with a sham device was seen when using a LPS adsorber in addition to standard care.en_US
dc.descriptionThis is a non-final version of an article published in final form in Lipcsey, Tenhunen, Pischke, Kuitunen, Flaatten, De Geer, Sjölin, Frithiof, Chew, Bendel, Kawati, Larsson, Mollnes, Tønnessen, Rubertsson. Endotoxin removal in septic shock with the Alteco LPS Adsorber was safe but showed no benefit compared to placebo in the double-blind randomized controlled trial - the Asset Study. Shock. 2020;54(2):224-231.en_US
dc.identifier.citationLipcsey, Tenhunen, Pischke, Kuitunen, Flaatten, De Geer, Sjölin, Frithiof, Chew, Bendel, Kawati, Larsson, Mollnes, Tønnessen, Rubertsson. Endotoxin removal in septic shock with the Alteco LPS Adsorber was safe but showed no benefit compared to placebo in the double-blind randomized controlled trial - the Asset Study. Shock. 2020;54(2):224-231en_US
dc.identifier.cristinIDFRIDAID 1771083
dc.identifier.doi10.1097/SHK.0000000000001503
dc.identifier.issn1073-2322
dc.identifier.issn1540-0514
dc.identifier.urihttps://hdl.handle.net/10037/21168
dc.language.isoengen_US
dc.publisherLippincott, Williams & Wilkinsen_US
dc.relation.journalShock
dc.relation.projectIDNorges forskningsråd: 223255en_US
dc.relation.projectIDinfo:eu-repo/grantAgreement/RCN/SFF/223255/Norway/Centre of Molecular Inflammation Research/CEMIR/en_US
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright © 2019 by the Shock Societyen_US
dc.subjectVDP::Medical disciplines: 700en_US
dc.subjectVDP::Medisinske Fag: 700en_US
dc.titleEndotoxin removal in septic shock with the Alteco LPS Adsorber was safe but showed no benefit compared to placebo in the double-blind randomized controlled trial - the Asset Studyen_US
dc.type.versionacceptedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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