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dc.contributor.authorVinarov, Zahari
dc.contributor.authorAbrahamsson, Bertil
dc.contributor.authorArtursson, Per
dc.contributor.authorBatchelor, Hannah
dc.contributor.authorBerben, Philippe
dc.contributor.authorBernkop-Schnürch, Andreas
dc.contributor.authorButler, James
dc.contributor.authorCeulemans, Jens
dc.contributor.authorDavies, Nigel
dc.contributor.authorDupont, Didier
dc.contributor.authorFlaten, Gøril Eide
dc.contributor.authorFotaki, Nikoletta
dc.contributor.authorGriffin, Brendan T.
dc.contributor.authorJannin, Vincent
dc.contributor.authorKeemink, Janneke
dc.contributor.authorKesisoglou, Filippos
dc.contributor.authorKoziolek, Mirko
dc.contributor.authorKuentz, Martin
dc.contributor.authorMackie, Alan R.
dc.contributor.authorMeléndez-Martínez, Antonio J.
dc.contributor.authorMcAllister, Mark
dc.contributor.authorMüllertz, Anette
dc.contributor.authorO'Driscoll, Caitriona M.
dc.contributor.authorParrott, Neil
dc.contributor.authorPaszkowska, Jadwiga
dc.contributor.authorPavek, Petr
dc.contributor.authorPorter, Christopher J.H.
dc.contributor.authorReppas, Christos
dc.contributor.authorStillhart, Cordula
dc.contributor.authorSugano, Kiyohiko
dc.contributor.authorToader, Elena
dc.contributor.authorValentová, Kateřina
dc.contributor.authorVertzoni, Maria
dc.contributor.authorDe Wildt, Saskia N.
dc.contributor.authorWilson, Clive G.
dc.contributor.authorAugustijns, Patrick
dc.date.accessioned2021-06-16T10:26:55Z
dc.date.available2021-06-16T10:26:55Z
dc.date.issued2021-02-18
dc.description.abstractAlthough oral drug delivery is the preferred administration route and has been used for centuries, modern drug discovery and development pipelines challenge conventional formulation approaches and highlight the insufficient mechanistic understanding of processes critical to oral drug absorption. This review presents the opinion of UNGAP scientists on four key themes across the oral absorption landscape: (1) specific patient populations, (2) regional differences in the gastrointestinal tract, (3) advanced formulations and (4) food-drug interactions. The differences of oral absorption in pediatric and geriatric populations, the specific issues in colonic absorption, the formulation approaches for poorly water-soluble (small molecules) and poorly permeable (peptides, RNA etc.) drugs, as well as the vast realm of food effects, are some of the topics discussed in detail. The identified controversies and gaps in the current understanding of gastrointestinal absorption-related processes are used to create a roadmap for the future of oral drug absorption research.en_US
dc.identifier.citationVinarov, Abrahamsson, Artursson, Batchelor, Berben, Bernkop-Schnürch, Butler, Ceulemans, Davies, Dupont, Flaten, Fotaki, Griffin, Jannin, Keemink, Kesisoglou, Koziolek, Kuentz, Mackie, Meléndez-Martínez, McAllister, Müllertz, O'Driscoll, Parrott, Paszkowska, Pavek, Porter, Reppas, Stillhart, Sugano, Toader, Valentová, Vertzoni, De Wildt, Wilson, Augustijns. Current challenges and future perspectives in oral absorption research: An opinion of the UNGAP network. Advanced Drug Delivery Reviews. 2021;171:289-331en_US
dc.identifier.cristinIDFRIDAID 1915712
dc.identifier.doi10.1016/j.addr.2021.02.001
dc.identifier.issn0169-409X
dc.identifier.issn1872-8294
dc.identifier.urihttps://hdl.handle.net/10037/21454
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.relation.journalAdvanced Drug Delivery Reviews
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/Horizon2020/?/?/?/?/en_US
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2021 The Author(s)en_US
dc.subjectVDP::Medical disciplines: 700::Basic medical, dental and veterinary science disciplines: 710::Pharmacology: 728en_US
dc.subjectVDP::Medisinske Fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710::Farmakologi: 728en_US
dc.titleCurrent challenges and future perspectives in oral absorption research: An opinion of the UNGAP networken_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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