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dc.contributor.authorSharifi, Sina
dc.contributor.authorIslam, Mohammad Mirazul
dc.contributor.authorSharifi, Hannah
dc.contributor.authorIslam, Rakibul
dc.contributor.authorKoza, Darrell
dc.contributor.authorReyes-Ortega, Felisa
dc.contributor.authorAlba-Molina, David
dc.contributor.authorNilsson, Per
dc.contributor.authorDohlman, Claes H.
dc.contributor.authorMollnes, Tom Eirik
dc.contributor.authorChodosh, James
dc.contributor.authorGonzalez-Andrades, Miguel
dc.date.accessioned2021-06-28T11:44:29Z
dc.date.available2021-06-28T11:44:29Z
dc.date.issued2021-04-17
dc.description.abstractGelatin based adhesives have been used in the last decades in different biomedical applications due to the excellent biocompatibility, easy processability, transparency, non-toxicity, and reasonable mechanical properties to mimic the extracellular matrix (ECM). Gelatin adhesives can be easily tuned to gain different viscoelastic and mechanical properties that facilitate its ocular application. We herein grafted glycidyl methacrylate on the gelatin backbone with a simple chemical modification of the precursor, utilizing epoxide ring-opening reactions and visible light-crosslinking. This chemical modification allows the obtaining of an elastic protein-based hydrogel (GELGYM) with excellent biomimetic properties, approaching those of the native tissue. GELGYM can be modulated to be stretched up to 4 times its initial length and withstand high tensile stresses up to 1.95 MPa with compressive strains as high as 80% compared to Gelatin-methacryloyl (GeIMA), the most studied derivative of gelatin used as a bioadhesive. GELGYM is also highly biocompatible and supports cellular adhesion, proliferation, and migration in both 2 and 3-dimensional cell-cultures. These characteristics along with its super adhesion to biological tissues such as cornea, aorta, heart, muscle, kidney, liver, and spleen suggest widespread applications of this hydrogel in many biomedical areas such as transplantation, tissue adhesive, wound dressing, bioprinting, and drug and cell delivery.en_US
dc.identifier.citationSharifi, Islam, Sharifi, Islam, Koza, Reyes-Ortega, Alba-Molina, Nilsson, Dohlman, Mollnes, Chodosh, Gonzalez-Andrades. Tuning gelatin-based hydrogel towards bioadhesive ocular tissue engineering applications. Bioactive Materials. 2021;6(11):3947-3961en_US
dc.identifier.cristinIDFRIDAID 1916730
dc.identifier.doi10.1016/j.bioactmat.2021.03.042
dc.identifier.issn2452-199X
dc.identifier.urihttps://hdl.handle.net/10037/21582
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.relation.journalBioactive Materials
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2021 The Author(s)en_US
dc.subjectVDP::Medical disciplines: 700::Basic medical, dental and veterinary science disciplines: 710en_US
dc.subjectVDP::Medisinske Fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710en_US
dc.titleTuning gelatin-based hydrogel towards bioadhesive ocular tissue engineering applicationsen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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