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dc.contributor.authorNøst, Therese H.
dc.contributor.authorHolden, Marit
dc.contributor.authorDønnem, Tom
dc.contributor.authorBøvelstad, Hege
dc.contributor.authorRylander, Charlotta
dc.contributor.authorLund, Eiliv
dc.contributor.authorSandanger, Torkjel M.
dc.date.accessioned2021-06-28T12:49:03Z
dc.date.available2021-06-28T12:49:03Z
dc.date.issued2021-04-01
dc.description.abstractRecent studies have indicated that there are functional genomic signals that can be detected in blood years before cancer diagnosis. This study aimed to assess gene expression in prospective blood samples from the Norwegian Women and Cancer cohort focusing on time to lung cancer diagnosis and metastatic cancer using a nested case–control design. We employed several approaches to statistically analyze the data and the methods indicated that the case–control differences were subtle but most distinguishable in metastatic case–control pairs in the period 0–3 years prior to diagnosis. The genes of interest along with estimated blood cell populations could indicate disruption of immunological processes in blood. The genes identified from approaches focusing on alterations with time to diagnosis were distinct from those focusing on the case–control differences. Our results support that explorative analyses of prospective blood samples could indicate circulating signals of disease-related processes.en_US
dc.identifier.citationNøst, Holden, Dønnem, Bøvelstad, Rylander, Lund, Sandanger. Transcriptomic signals in blood prior to lung cancer focusing on time to diagnosis and metastasis. Scientific Reports. 2021;11(1):1-11en_US
dc.identifier.cristinIDFRIDAID 1918018
dc.identifier.doi10.1038/s41598-021-86879-8
dc.identifier.issn2045-2322
dc.identifier.urihttps://hdl.handle.net/10037/21587
dc.language.isoengen_US
dc.publisherNature Researchen_US
dc.relation.journalScientific Reports
dc.relation.projectIDinfo:eu-repo/grantAgreement/RCN/?/232997/?/?/?/en_US
dc.relation.projectIDinfo:eu-repo/grantAgreement/RCN/?/213577/?/?/?/en_US
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2021 The Author(s)en_US
dc.subjectVDP::Medical disciplines: 700::Basic medical, dental and veterinary science disciplines: 710en_US
dc.subjectVDP::Medisinske Fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710en_US
dc.titleTranscriptomic signals in blood prior to lung cancer focusing on time to diagnosis and metastasisen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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