dc.contributor.author | Kloos, Julia Maria | |
dc.contributor.author | Gama, João Alves | |
dc.contributor.author | Hegstad, Joachim | |
dc.contributor.author | Samuelsen, Ørjan | |
dc.contributor.author | Johnsen, Pål Jarle | |
dc.date.accessioned | 2021-07-07T11:51:40Z | |
dc.date.available | 2021-07-07T11:51:40Z | |
dc.date.issued | 2021-03-24 | |
dc.description.abstract | The persistence of plasmids in bacterial populations represents a puzzling evolutionary problem with serious clinical implications due to their role in the ongoing antibiotic resistance crisis. Recently, major advancements have been made toward resolving this “plasmid paradox” but mainly in a nonclinical context. Here, we propose an additional explanation for the maintenance of multidrug‐resistance plasmids in clinical Escherichia coli strains. After coevolving two multidrug‐resistance plasmids encoding resistance to last resort carbapenems with an extraintestinal pathogenic E. coli strain, we observed that chromosomal media adaptive mutations in the global regulatory systems CCR (carbon catabolite repression) and ArcAB (aerobic respiration control) pleiotropically improved the maintenance of both plasmids. Mechanistically, a net downregulation of plasmid gene expression reduced the fitness cost. Our results suggest that global chromosomal transcriptional rewiring during bacterial niche adaptation may facilitate plasmid maintenance. | en_US |
dc.identifier.citation | Kloos JM, Gama J, Hegstad J, Samuelsen Ø, Johnsen Pj. Piggybacking on Niche Adaptation Improves the Maintenance of Multidrug-Resistance Plasmids. Molecular Biology and Evolution (MBE). 2021 | en_US |
dc.identifier.cristinID | FRIDAID 1920497 | |
dc.identifier.doi | https://doi.org/10.1093/molbev/msab091 | |
dc.identifier.issn | 0737-4038 | |
dc.identifier.issn | 1537-1719 | |
dc.identifier.uri | https://hdl.handle.net/10037/21818 | |
dc.language.iso | eng | en_US |
dc.publisher | Oxford University Press | en_US |
dc.relation.journal | Molecular Biology and Evolution (MBE) | |
dc.rights.accessRights | openAccess | en_US |
dc.rights.holder | Copyright 2021 The Author(s) | en_US |
dc.subject | VDP::Medical disciplines: 700::Basic medical, dental and veterinary science disciplines: 710::Pharmacology: 728 | en_US |
dc.subject | VDP::Medisinske Fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710::Farmakologi: 728 | en_US |
dc.title | Piggybacking on Niche Adaptation Improves the Maintenance of Multidrug-Resistance Plasmids | en_US |
dc.type.version | publishedVersion | en_US |
dc.type | Journal article | en_US |
dc.type | Tidsskriftartikkel | en_US |
dc.type | Peer reviewed | en_US |