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dc.contributor.authorHaugnes, Hege S.
dc.contributor.authorNegaard, Helene F.
dc.contributor.authorNegaard, Helene Francisca Stigter
dc.contributor.authorJensvoll, Hilde
dc.contributor.authorWilsgaard, Tom
dc.contributor.authorTandstad, Torgrim
dc.contributor.authorSolberg, Arne
dc.date.accessioned2021-09-08T08:59:54Z
dc.date.available2021-09-08T08:59:54Z
dc.date.issued2021-08-15
dc.description.abstract<i>Background</i> - Cisplatin-based chemotherapy (CBCT) in testicular cancer (TC) is associated with elevated venous thromboembolism (VTE) risk, but trials evaluating the safety and efficacy of thromboprophylaxis are lacking.<br><br> <i>Objective</i> - To evaluate the arterial thromboembolism (ATE) and VTE incidence and risk factors during first-line CBCT for metastatic TC, and the effect of thromboprophylaxis on VTE and bleeding.<br><br> <i>Design, setting, and participants</i> - In a population-based study, 506 men administered first-line CBCT during 2000–2014 at three university hospitals in Norway were included. Clinical variables were retrieved from medical records. Outcome measurements and statistical analysis Patients with ATE and VTE diagnosed at initiation of or during CBCT until 3 mo after completion were registered. Age-adjusted logistic regression was performed to identify possible VTE risk factors.<br><br> <i>Results and limitations</i> - Overall, 69 men (13.6%) were diagnosed with 70 thromboembolic events. Twelve men (2.4%) experienced ATE. Overall, 58 men (11.5%) experienced VTE, of whom 13 (2.6%) were prevalent at CBCT initiation, while 45 (8.9%) were diagnosed with incident VTE. Age-adjusted logistic regression identified retroperitoneal lymph node metastasis >5 cm (odds ratio [OR] 1.99, 95% confidence interval [CI] 1.01–3.91), central venous access (OR 2.84, 95% CI 1.46–5.50), and elevated C-reactive protein (>5 mg/l; OR 2.38, 95% CI 1.12–5.07) as incident VTE risk factors. Thromboprophylaxis (n = 84) did not influence the risk of VTE (VTE incidence with or without prophylaxis 13% vs 8%, p = 0.16). The incidence of bleeding events was significantly higher among those who received thromboprophylaxis than among those without thromboprophylaxis (14.5% vs 1.1%, p < 0.001).<br><br> <i>Conclusions</i> - We found a high rate of thromboembolism incidence of 13.6%. Thromboprophylaxis did not decrease the risk of VTE but was associated with an increased risk of bleeding.<br><br> <i>Patient summary</i> - We found a high rate of thromboembolism (13.6%) during cisplatin-based chemotherapy for metastatic testicular cancer. Prophylactic treatment against thromboses did not reduce the thrombosis frequency, but it resulted in a high incidence of bleeding events.en_US
dc.identifier.citationHaugnes, Negaard, Negaard HFS, Jensvoll, Wilsgaard, Tandstad, Solberg. Thromboembolic Events During Treatment with Cisplatin-based Chemotherapy in Metastatic Testicular Germ-cell Cancer 2000–2014: A Population-based Cohort Study. European Urology Open Science. 2021;32:19-27en_US
dc.identifier.cristinIDFRIDAID 1929868
dc.identifier.doi10.1016/j.euros.2021.07.007
dc.identifier.issn2666-1691
dc.identifier.issn2666-1683
dc.identifier.urihttps://hdl.handle.net/10037/22452
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.relation.journalEuropean Urology Open Science
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2021 The Author(s)en_US
dc.subjectVDP::Medical disciplines: 700en_US
dc.subjectVDP::Medisinske Fag: 700en_US
dc.titleThromboembolic Events During Treatment with Cisplatin-based Chemotherapy in Metastatic Testicular Germ-cell Cancer 2000–2014: A Population-based Cohort Studyen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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