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dc.contributor.authorButt, Julia
dc.contributor.authorJenab, Mazda
dc.contributor.authorWerner, Jill
dc.contributor.authorFedirko, Veronika
dc.contributor.authorWeiderpass, Elisabete
dc.contributor.authorDahm, Christina C.
dc.contributor.authorTjønneland, Anne
dc.contributor.authorOlsen, Anja
dc.contributor.authorBoutron-Ruault, Marie-Christine
dc.contributor.authorRothwell, Joseph A.
dc.contributor.authorSeveri, Gianluca
dc.contributor.authorKaaks, Rudolf
dc.contributor.authorTurzanski-Fortner, Renée
dc.contributor.authorAleksandrova, Krasimira
dc.contributor.authorSchulze, Matthias B.
dc.contributor.authorPalli, Domenico
dc.contributor.authorPala, Valeria
dc.contributor.authorPanico, Salvatore
dc.contributor.authorTumino, Rosaria
dc.contributor.authorSacerdote, Carlotta
dc.contributor.authorBueno-De-Mesquita, Bas
dc.contributor.authorvan Gils, Carla H.
dc.contributor.authorGram, Inger Torhild
dc.contributor.authorLukic, Marko
dc.contributor.authorSala, Núria
dc.contributor.authorSánchez Pérez, Maria José
dc.contributor.authorArdanaz, Eva
dc.contributor.authorChirlaque, Maria-Dolores
dc.contributor.authorPalmquist, Richard
dc.contributor.authorLöwenmark, Thyra
dc.contributor.authorTravis, Ruth C.
dc.contributor.authorHeath, Alicia K.
dc.contributor.authorCross, Amanda J.
dc.contributor.authorFreisling, Heinz
dc.contributor.authorZouiouich, Semi
dc.contributor.authorAglago, Elom
dc.contributor.authorWaterboer, Tim
dc.contributor.authorHughes, David J.
dc.date.accessioned2021-10-05T08:49:39Z
dc.date.available2021-10-05T08:49:39Z
dc.date.issued2021-04-20
dc.description.abstractExperimental evidence has implicated genotoxic <i>Escherichia coli (E. coli)</i> and enterotoxigenic <i>Bacteroides fragilis</i> (ETBF) in the development of colorectal cancer (CRC). However, evidence from epidemiological studies is sparse. We therefore assessed the association of serological markers of <i>E. coli</i> and ETBF exposure with odds of developing CRC in the European Prospective Investigation into Nutrition and Cancer (EPIC) study.<br><br> Serum samples of incident CRC cases and matched controls (n = 442 pairs) were analyzed for immunoglobulin (Ig) A and G antibody responses to seven <i>E. coli</i> proteins and two isoforms of the ETBF toxin via multiplex serology. Multivariable-adjusted conditional logistic regression analyses were used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for the association of sero-positivity to <i>E. coli</i> and ETBF with CRC.<br><br> The IgA-positivity of any of the tested <i>E. coli</i> antigens was associated with higher odds of developing CRC (OR: 1.42; 95% CI: 1.05–1.91). Dual-positivity for both IgA and IgG to <i>E. coli</i> and ETBF was associated with >1.7-fold higher odds of developing CRC, with a significant association only for IgG (OR: 1.75; 95% CI: 1.04, 2.94). This association was more pronounced when restricted to the proximal colon cancers (OR: 2.62; 95% CI: 1.09, 6.29) compared to those of the distal colon (OR: 1.24; 95% CI: 0.51, 3.00) (<i>pheterogeneity</i> = 0.095). Sero-positivity to <i>E. coli</i> and ETBF was associated with CRC development, suggesting that co-infection of these bacterial species may contribute to colorectal carcinogenesis. These findings warrant further exploration in larger prospective studies and within different population groups.en_US
dc.identifier.citationButt, Jenab, Werner, Fedirko, Weiderpass, Dahm, Tjønneland, Olsen, Boutron-Ruault, Rothwell, Severi, Kaaks, Turzanski-Fortner, Aleksandrova, Schulze, Palli, Pala, Panico, Tumino, Sacerdote, Bueno-De-Mesquita, van Gils, Gram, Lukic, Sala, Sánchez Pérez, Ardanaz, Chirlaque, Palmquist, Löwenmark, Travis, Heath, Cross, Freisling, Zouiouich, Aglago, Waterboer, Hughes. Association of Pre-diagnostic Antibody Responses to Escherichia coli and Bacteroides fragilis Toxin Proteins with Colorectal Cancer in a European Cohort. Gut microbes. 2021;13(1):1-14en_US
dc.identifier.cristinIDFRIDAID 1925335
dc.identifier.doi10.1080/19490976.2021.1903825
dc.identifier.issn1949-0976
dc.identifier.issn1949-0984
dc.identifier.urihttps://hdl.handle.net/10037/22717
dc.language.isoengen_US
dc.publisherTaylor & Francisen_US
dc.relation.journalGut microbes
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/?/?/EU/?/?/en_US
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2021 The Author(s)en_US
dc.subjectVDP::Medical disciplines: 700en_US
dc.subjectVDP::Medisinske Fag: 700en_US
dc.titleAssociation of Pre-diagnostic Antibody Responses to Escherichia coli and Bacteroides fragilis Toxin Proteins with Colorectal Cancer in a European Cohorten_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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