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dc.contributor.authorAna-Lucia, Mayén
dc.contributor.authorAglago, Elom K.
dc.contributor.authorKnaze, Viktoria
dc.contributor.authorCordova, Reynalda
dc.contributor.authorSchalkwijk, Casper G.
dc.contributor.authorWagner, Karl-Heinz
dc.contributor.authorAleksandrova, Krasimira
dc.contributor.authorFedirko, Veronika
dc.contributor.authorKeski-Rahkonen, Pekka
dc.contributor.authorLeitzmann, Michael F.
dc.contributor.authorKatzke, Verena
dc.contributor.authorSrour, Bernard
dc.contributor.authorSchulze, Matthias B.
dc.contributor.authorMasala, Giovanna
dc.contributor.authorKrogh, Vittorio
dc.contributor.authorPanico, Salvatore
dc.contributor.authorTumino, Rosario
dc.contributor.authorBueno-de-Mesquita, Bas
dc.contributor.authorBrustad, Magritt
dc.contributor.authorAgudo, Antonio
dc.contributor.authorLópez, María Dolores Chirlaque
dc.contributor.authorAmiano, Pilar
dc.contributor.authorOhlsson, Bodil
dc.contributor.authorRamne, Stina
dc.contributor.authorAune, Dagfinn
dc.contributor.authorWeiderpass, Elisabete
dc.contributor.authorJenab, Mazda
dc.contributor.authorFreisling, Heinz
dc.date.accessioned2021-11-16T10:09:45Z
dc.date.available2021-11-16T10:09:45Z
dc.date.issued2021-04-25
dc.description.abstractAdvanced glycation endproducts (AGEs) may contribute to liver carcinogenesis because of their proinflammatory and prooxidative properties. Diet is a major source of AGEs, but there is sparse human evidence on the role of AGEs intake in liver cancer etiology. We examined the association between dietary AGEs and the risk of hepatobiliary cancers in the European Prospective Investigation into Cancer and Nutrition prospective cohort (n = 450 111). Dietary intake of three AGEs, N<sup>ε</sup> -[carboxymethyl]lysine (CML), N<sup>ε</sup> -[1-carboxyethyl]lysine (CEL) and N<sup>δ</sup> -[5-hydro-5-methyl4-imidazolon-2-yl]-ornithine (MG-H1), was estimated using country-specific dietary questionnaires linked to an AGEs database. Cause-specific hazard ratios (HR) and their 95% confidence intervals (CI) for associations between dietary AGEs and risk of hepatocellular carcinoma (HCC), gallbladder and biliary tract cancers were estimated using multivariable Cox proportional hazard regression. After a median follow-up time of 14.9 years, 255 cases of HCC, 100 cases of gallbladder cancer and 173 biliary tract cancers were ascertained. Higher intakes of dietary AGEs were inversely associated with the risk of HCC (per 1 SD increment, HR-CML = 0.87, 95% CI: 0.76-0.99, HR-<sub>CEL</sub> = 0.84, 95% CI: 0.74-0.96 and HR-<sub>MH-G1</sub> = 0.84, 95% CI: 0.74-0.97). In contrast, positive associations were observed with risk of gallbladder cancer (per 1 SD, HR-<sub>CML</sub> = 1.28, 95% CI: 1.05-1.56, HR-<sub>CEL</sub> = 1.17; 95% CI: 0.96-1.40, HR-<sub>MHG1</sub> = 1.27, 95% CI: 1.06-1.54). No associations were observed for cancers of the intra and extrahepatic bile ducts. Our findings suggest that higher intakes of dietary AGEs are inversely associated with the risk of HCC and positively associated with the risk of gallbladder cancer.en_US
dc.identifier.citationAna-Lucia, Aglago, Knaze, Cordova, Schalkwijk, Wagner, Aleksandrova, Fedirko, Keski-Rahkonen, Leitzmann, Katzke, Srour, Schulze, Masala, Krogh, Panico, Tumino, Bueno-de-Mesquita, Brustad, Agudo, López, Amiano, Ohlsson, Ramne, Aune, Weiderpass, Jenab, Freisling. Dietary intake of advanced glycation endproducts and risk of hepatobiliary cancers: A multinational cohort study. International Journal of Cancer. 2021en_US
dc.identifier.cristinIDFRIDAID 1915957
dc.identifier.doi10.1002/ijc.33612
dc.identifier.issn0020-7136
dc.identifier.issn1097-0215
dc.identifier.urihttps://hdl.handle.net/10037/23012
dc.language.isoengen_US
dc.publisherWileyen_US
dc.relation.journalInternational Journal of Cancer
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2021 The Author(s)en_US
dc.subjectVDP::Medical disciplines: 700::Health sciences: 800::Community medicine, Social medicine: 801en_US
dc.subjectVDP::Medisinske Fag: 700::Helsefag: 800::Samfunnsmedisin, sosialmedisin: 801en_US
dc.subjectVDP::Medical disciplines: 700::Clinical medical disciplines: 750::Oncology: 762en_US
dc.subjectVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Onkologi: 762en_US
dc.titleDietary intake of advanced glycation endproducts and risk of hepatobiliary cancers: A multinational cohort studyen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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