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dc.contributor.authorPerrier, Flavie
dc.contributor.authorGhiasvand, Reza
dc.contributor.authorLergenmuller, Simon
dc.contributor.authorRobsahm, Trude Eid
dc.contributor.authorGreen, Adele C.
dc.contributor.authorBorch, Kristin Benjaminsen
dc.contributor.authorSandanger, Torkjel M
dc.contributor.authorWeiderpass, Elisabete
dc.contributor.authorRueegg, Corina Silvia
dc.contributor.authorVeierød, Marit Bragelien
dc.date.accessioned2021-11-29T13:57:41Z
dc.date.available2021-11-29T13:57:41Z
dc.date.issued2021-04-20
dc.description.abstractPhysical activity (PA) is an important factor in cancer prevention, but positive association between PA and risk of cutaneous melanoma found in recent studies may complicate this strategy. Ultraviolet radiation (UVR) exposure during outdoor PA is a plausible explanation for a positive association. We investigated the associations between PA, UVR and melanoma risk in the Norwegian Women and Cancer cohort. Overall PA was reported by 151,710 women, aged 30–75 at inclusion, using a validated 10-point-scale at enrolment and during follow-up, together with recent numbers of sunburns, indoor tanning sessions and weeks on sunbathing vacations. Seasonal outdoor walking and seasonal PAs were recorded in subsamples (n = 102,671 and n = 29,077, respectively). Logistic and Cox regression were used. Mean follow-up was 18.5 years, and 1565 invasive incident melanoma cases were diagnosed. Overall PA was inversely associated with sunburns, while positively associated with sunbathing vacations and indoor tanning. Overall PA was not associated with melanoma risk in all body sites combined (ptrend = 0.61), but reduced risk was found in upper limb melanomas (hazard ratio (HR) = 0.70, 95% confidence interval (CI) 0.51–0.96; high versus low PA). Non-significant reduced risks were found for seasonal outdoor walking >2 h/day versus 30–60 min/day (summer HR = 0.81, 95% CI 0.66–1.00; autumn HR = 0.74, 95%CI 0.55–1.01). Seasonal PAs were not associated with melanoma risk. In conclusion, we found positive associations between overall PA and sunbathing vacations and indoor tanning, and, unlike literature, inverse association between overall PA and sunburns. Our results do not support a positive association between PA and melanoma risk in Norwegian women.en_US
dc.identifier.citationPerrier, Ghiasvand, Lergenmuller, Robsahm, Green, Borch, Sandanger, Weiderpass, Rueegg, Veierød. Physical activity and cutaneous melanoma risk: A Norwegian population-based cohort study. Preventive Medicine. 2021;153:106556:1-9en_US
dc.identifier.cristinIDFRIDAID 1936517
dc.identifier.doi10.1016/j.ypmed.2021.106556
dc.identifier.issn0091-7435
dc.identifier.issn1096-0260
dc.identifier.urihttps://hdl.handle.net/10037/23205
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.relation.journalPreventive Medicine
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2021 The Author(s)en_US
dc.subjectVDP::Medical disciplines: 700::Health sciences: 800::Community medicine, Social medicine: 801en_US
dc.subjectVDP::Medisinske Fag: 700::Helsefag: 800::Samfunnsmedisin, sosialmedisin: 801en_US
dc.titlePhysical activity and cutaneous melanoma risk: A Norwegian population-based cohort studyen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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