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dc.contributor.authorSchmalfuss, Andreas Jörn
dc.contributor.authorSehic, Amer
dc.contributor.authorBrusevold, Ingvild Johnsen
dc.date.accessioned2021-12-06T11:43:20Z
dc.date.available2021-12-06T11:43:20Z
dc.date.issued2021-10-29
dc.description.abstractPurpose Identifying factors causing Molar-Incisor Hypomineralization (MIH) is an ongoing challenge. Preterm infants, routinely treated with antibiotics in cases of suspected sepsis, are more commonly afected by dental developmental defects. This study aimed to investigate the efects of gentamycin and ampicillin on the developing enamel in neonatal CD-1 mice in vivo.<p> <p>Methods Neonatal mice were randomized into a study (n=36) and a control (n=35) group. Antibiotics were injected intravenously for 4 days. All mice were sacrifced after 15–18 days. Micro-CT was used to analyse the mineral density (MD) of the enamel and the proportion of the enamel object volume (vol%) in frst molars and incisors.<p> <p>Results We demonstrated a signifcantly lower vol% enamel in the maxillary (30.9% vs. 32.7%; p=0.004) and mandibular (32.5% vs. 34.6%; p=0.015) molars in the study group than in the controls. The incisors were divided into segments upon analysis. We demonstrated both lower vol% and lower MD of the enamel in most segments in treated individuals compared to controls (p<0.05).<p> <p>Conclusion The reduced MD and vol% in the molars and incisors are likely to have been caused by the antibiotics given during tooth development. The presented analysis of teeth in neonatal mice with micro-CT could be a valid model for further research on dental developmental defects.en_US
dc.identifier.citationSchmalfuss, Sehic, Brusevold. Effects of antibiotics on the developing enamel in neonatal mice. European Archives of Paediatric Dentistry. 2021:1-10en_US
dc.identifier.cristinIDFRIDAID 1954222
dc.identifier.doi10.1007/s40368-021-00677-4
dc.identifier.issn1818-6300
dc.identifier.issn1996-9805
dc.identifier.urihttps://hdl.handle.net/10037/23290
dc.language.isoengen_US
dc.publisherSpringeren_US
dc.relation.ispartofSchmalfuss, A.J. (2022). Molar-Incisor Hypomineralization (MIH). Prevalence among 16-year-old adolescents: A case-control study of children with a low Apgar score at birth and a study on tooth formation and antibiotics in mice. (Doctoral thesis). <a href=https://hdl.handle.net/10037/24706>https://hdl.handle.net/10037/24706</a>.
dc.relation.journalEuropean Archives of Paediatric Dentistry
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2021 The Author(s)en_US
dc.subjectVDP::Medical disciplines: 700::Clinical dentistry disciplines: 830en_US
dc.subjectVDP::Medisinske Fag: 700::Klinisk odontologiske fag: 830en_US
dc.titleEffects of antibiotics on the developing enamel in neonatal miceen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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