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dc.contributor.authorKrzyscik, Mateusz Adam
dc.contributor.authorZakrzewska, Malgorzata
dc.contributor.authorSørensen, Vigdis
dc.contributor.authorØy, Geir Frode
dc.contributor.authorBruheim, Skjalg
dc.contributor.authorHaugsten, Ellen Margrethe
dc.contributor.authorMælandsmo, Gunhild Mari
dc.contributor.authorWiedlocha, Antoni
dc.contributor.authorOtlewski, Jacek
dc.date.accessioned2021-12-07T14:44:26Z
dc.date.available2021-12-07T14:44:26Z
dc.date.issued2021-09-20
dc.description.abstractWorldwide, cancer is the second leading cause of death. Regardless of the continuous progress in medicine, we still do not have a fully effective anti-cancer therapy. Therefore, the search for new targeted anti-cancer drugs is still an unmet need. Here, we present novel protein–drug conjugates that inhibit tumor growth in a mouse model of human breast cancer. We developed conjugates based on fibroblast growth factor (FGF2) with improved biophysical and biological properties for the efficient killing of cancer cells overproducing fibroblast growth factor receptor 1 (FGFR1). We used hydrophilic and biocompatible PEG4 or PEG27 molecules as a spacer between FGF2 and the toxic agent monomethyl auristatin E. All conjugates exhibited a cytotoxic effect on FGFR1-positive cancer cell lines. The conjugate with the highest hydrodynamic size (42 kDa) and cytotoxicity was found to efficiently inhibit tumor growth in a mouse model of human breast cancer.en_US
dc.identifier.citationKrzyscik, Zakrzewska, Sørensen, Øy, Bruheim, Haugsten, Mælandsmo, Wiedlocha, Otlewski. Fibroblast growth factor 2 conjugated with monomethyl auristatin E inhibits tumor growth in a mouse model. Biomacromolecules. 2021;22(10):4169-4180en_US
dc.identifier.cristinIDFRIDAID 1956204
dc.identifier.doi10.1021/acs.biomac.1c00662
dc.identifier.issn1525-7797
dc.identifier.issn1526-4602
dc.identifier.urihttps://hdl.handle.net/10037/23312
dc.language.isoengen_US
dc.publisherAmerican Chemical Societyen_US
dc.relation.journalBiomacromolecules
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2021 The Author(s)en_US
dc.subjectVDP::Medical disciplines: 700::Basic medical, dental and veterinary science disciplines: 710en_US
dc.subjectVDP::Medisinske Fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710en_US
dc.titleFibroblast growth factor 2 conjugated with monomethyl auristatin E inhibits tumor growth in a mouse modelen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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