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dc.contributor.advisorStraume, Bjørn
dc.contributor.advisorPaulssen, Eyvind J.
dc.contributor.authorAsfeldt, Anne Mette
dc.date.accessioned2009-12-22T07:54:51Z
dc.date.available2009-12-22T07:54:51Z
dc.date.issued2009-04-24
dc.description.abstractDyspepsia is a highly prevalent condition, involving substantial health-care resources. Ever since Marshall and Warren in 1984 discovered that Helicobacter pylori could cause peptic ulcer, it has been discussed to what extend Helicobacter pylori play a role in dyspepsia in general. In 2004 a population based survey was carried out in the municipality of Sørreisa, comprising a questionnaire survey on gastrointestinal disorders and upper endoscopy of a subgroup of the population. The results from this survey were compared with a similar survey in Sørreisa from 1987. <br><br>Main Results <br>A diagnostic test, the “Amplified IDEIA Hp StAR®” (DakoCytomation, Denmark) was validated and found to be very accurate, also in patients using proton pump inhibitors. The observer variability in upper endoscopy was studied and found to be considerable. A systematic image documentation of the endoscopy findings, regardless of suspicion of pathology, would improve the quality of the procedure. The prevalence of H. pylori has decreased considerably since 1987, whereas the prevalence of dyspepsia has remained constant, thus questioning any relationship between the two. Helicobacter pylori is only a moderate risk factor for peptic ulcer, whereas other risk factors as smoking seems to be just as important. Helicobacter pylori causes inflammation of the gastric mucosa, but plays a minor role in more chronic changes of the gastric mucosa such as atrophy and intestinal metaplasia. Elimination of Helicobacter pylori infection causes regression of inflammation, but not regression of intestinal metaplasia once it has developed. <br><br>The thesis emanate from the Department of Community and the department of Clinical Medicine, University of Tromsø, Norwayen
dc.descriptionPaper number 3 of the thesis is not available in Munin due to publisher's restrictions: <br>3. Anne Mette Asfeldt, Bjørn Straume, Sonja Eriksson Steigen, Maja-Lisa Løchen, Jon Florholmen, Bjørn Bernersen, Roar Johnsen, Eyvind J. Paulssen: 'Changes in the prevalence of dyspepsia and Helicobacter pylori infection after 17 years: The Sørreisa gastrointestinal disorder study' European journal of epidemiology (2008) 23:625–633 (Springer). Available at <a href=http://dx.doi.org/10.1007/s10654-008-9275-x>http://dx.doi.org/10.1007/s10654-008-9275-x</a>en
dc.format.extent9478774 bytes
dc.format.mimetypeapplication/pdf
dc.identifier.isbn978-82-90263-12-1
dc.identifier.issn0801-017x
dc.identifier.urihttps://hdl.handle.net/10037/2331
dc.identifier.urnURN:NBN:no-uit_munin_2081
dc.language.isoengen
dc.publisherUniversitetet i Tromsøen
dc.publisherUniversity of Tromsøen
dc.relation.ispartofseriesISM skriftserie, nr 103en
dc.rights.accessRightsopenAccess
dc.rights.holderCopyright 2009 The Author(s)
dc.subjectVDP::Medisinske fag: 700::Klinisk medisinske fag: 750::Generell indremedisin: 770en
dc.subjectVDP::Medisinske fag: 700::Klinisk medisinske fag: 750::Gasteroenterologi: 773en
dc.subjectVDP::Medisinske fag: 700::Klinisk medisinske fag: 750::Infeksjonsmedisin: 776en
dc.subjectVDP::Medisinske fag: 700::Helsefag: 800::Samfunnsmedisin, sosialmedisin: 801en
dc.subjectVDP::Medisinske fag: 700::Helsefag: 800::Epidemiologi medisinsk og odontologisk statistikk: 803en
dc.subjectVDP::Medical disciplines: 700::Clinical medical disciplines: 750::General internal medicine: 770en
dc.subjectVDP::Medical disciplines: 700::Clinical medical disciplines: 750::Gastroenterology: 773en
dc.subjectVDP::Medical disciplines: 700::Clinical medical disciplines: 750::Communicable diseases: 776en
dc.subjectVDP::Medical disciplines: 700::Health sciences: 800::Community medicine, Social medicine: 801en
dc.subjectVDP::Medical disciplines: 700::Health sciences: 800::Epidemiology medical and dental statistics: 803en
dc.titleHelicobacter pylori and dyspepsia from a public health perspective : The Sørreisa Gastrointestinal Disorder Studyen
dc.typeDoctoral thesisen
dc.typeDoktorgradsavhandlingen


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