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dc.contributor.authorHellevik, Turid
dc.contributor.authorBerzaghi, Rodrigo
dc.contributor.authorLode, Kristin
dc.contributor.authorIslam, Md Ashraful
dc.contributor.authorMartinez, Inigo Zubiavrre
dc.date.accessioned2021-12-29T13:31:44Z
dc.date.available2021-12-29T13:31:44Z
dc.date.issued2021-10-18
dc.description.abstractRadiotherapy (RT) still represents a mainstay of treatment in clinical oncology. Traditionally, the effectiveness of radiotherapy has been attributed to the killing potential of ionizing radiation (IR) over malignant cells, however, it has become clear that therapeutic efficacy of RT also involves activation of innate and adaptive anti-tumor immune responses. Therapeutic irradiation of the tumor microenvironment (TME) provokes profound cellular and biological reconfigurations which ultimately may influence immune recognition. As one of the major constituents of the TME, cancer-associated fibroblasts (CAFs) play central roles in cancer development at all stages and are recognized contributors of tumor immune evasion. While some studies argue that RT affects CAFs negatively through growth arrest and impaired motility, others claim that exposure of fibroblasts to RT promotes their conversion into a more activated phenotype. Nevertheless, despite the well-described immunoregulatory functions assigned to CAFs, little is known about the interplay between CAFs and immune cells in the context of RT. In this review, we go over current literature on the effects of radiation on CAFs and the influence that CAFs have on radiotherapy outcomes, and we summarize present knowledge on the transformed cellular crosstalk between CAFs and immune cells after radiation.en_US
dc.identifier.citationHellevik T, Berzaghi RB, Lode K, Islam A, Martinez IZ. Immunobiology of cancer-associated fibroblasts in the context of radiotherapy. Journal of Translational Medicine. 2021en_US
dc.identifier.cristinIDFRIDAID 1944536
dc.identifier.doi10.1186/s12967-021-03112-w
dc.identifier.issn1479-5876
dc.identifier.urihttps://hdl.handle.net/10037/23551
dc.language.isoengen_US
dc.publisherBMCen_US
dc.relation.journalJournal of Translational Medicine
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2021 The Author(s)en_US
dc.subjectVDP::Medical disciplines: 700::Basic medical, dental and veterinary science disciplines: 710en_US
dc.subjectVDP::Medisinske Fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710en_US
dc.titleImmunobiology of cancer-associated fibroblasts in the context of radiotherapyen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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