Systolic and diastolic blood pressure, prostate cancer risk, treatment, and survival. The PROCA-life study
Permanent link
https://hdl.handle.net/10037/23833Date
2021-12-22Type
Journal articleTidsskriftartikkel
Peer reviewed
Author
Stikbakke, Einar; Schirmer, Henrik; Knutsen, Tore; Støyten, Martin; Wilsgaard, Tom; Giovannucci, Edward L.; McTiernan, Anne; Eggen, Anne Elise; Haugnes, Hege Sagstuen; Richardsen, Elin; Thune, IngerAbstract
Method: Using Cox regression models, we examined the association between prediagnostic BP and prostate cancer risk among 12,271 men participating in the Prostate Cancer throughout life (PROCA-life) study. Systolic and diastolic BP were measured. A total of 811 men developed prostate cancer, and followed for additional 7.1 years, and we studied the association between prediagnostic BP and overall mortality among patients with prostate cancer.
Results: Men (>45 years) with a systolic BP >150 mmHg had a 35% increased risk of prostate cancer compared with men with a normal systolic BP (<130 mmHg) (HR 1.35, 95% CI 1.08–1.69). Among patients with prostate cancer, men with systolic BP >150 mmHg had a 49% increased overall mortality compared with men with a normal systolic BP (HR 1.49, 1.06–2.01). Among patients with prostate cancer treated with curative intent, those with a high diastolic BP (>90 mmHg) had a threefold increase in overall mortality risk (HR 3.01, 95% CI 1.40–6.46) compared with patients with a normal diastolic BP (<80 mmHg).
Conclusion: Our results support that systolic and diastolic BP are important factors when balancing disease management in patients with prostate cancer.