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dc.contributor.authorJayasekara, Harindra
dc.contributor.authorMacInnis, Robert J.
dc.contributor.authorLujan-Barroso, Leila
dc.contributor.authorMayen-Chacon, Ana-Lucia
dc.contributor.authorCross, Amanda J.
dc.contributor.authorWallner, Bengt
dc.contributor.authorPalli, Domenico
dc.contributor.authorRicceri, Fulvio
dc.contributor.authorPala, Valeria
dc.contributor.authorPanico, Salvatore
dc.contributor.authorTumino, Rosario
dc.contributor.authorKühn, Tilman
dc.contributor.authorKaaks, Rudolf
dc.contributor.authorTsilidis, Konstantinos K.
dc.contributor.authorSánchez, Maria-Jose
dc.contributor.authorAmiano, Pilar
dc.contributor.authorArdanaz, Eva
dc.contributor.authorChirlaque López, María Dolores
dc.contributor.authorMerino, Susana
dc.contributor.authorBoutron-Ruault, Marie-Christine
dc.contributor.authorSeveri, Gianluca
dc.contributor.authorSternby, Hanna
dc.contributor.authorSonestedt, Emily
dc.contributor.authorBueno-de-Mesquita, Bas
dc.contributor.authorBoeing, Heiner
dc.contributor.authorTravis, Ruth C.
dc.contributor.authorSandanger, Torkjel M
dc.contributor.authorTrichopoulou, Antonia
dc.contributor.authorKarakatsani, Anna
dc.contributor.authorPeppa, Eleni
dc.contributor.authorTjønneland, Anne
dc.contributor.authorYang, Yi
dc.contributor.authorHodge, Allison M.
dc.contributor.authorMitchell, Hazel
dc.contributor.authorHaydon, Andrew
dc.contributor.authorRoom, R
dc.contributor.authorHopper, John L.
dc.contributor.authorWeiderpass, Elisabete
dc.contributor.authorGunter, Marc J.
dc.contributor.authorRiboli, Elio
dc.contributor.authorGiles, Graham G.
dc.contributor.authorMilne, Roger L.
dc.contributor.authorAgudo, Antonio
dc.contributor.authorEnglish, Dallas R.
dc.contributor.authorFerrari, Pietro
dc.date.accessioned2022-02-26T13:25:54Z
dc.date.available2022-02-26T13:25:54Z
dc.date.issued2021-02-07
dc.description.abstractAlcohol consumption is causally linked to several cancers but the evidence for stomach cancer is inconclusive. In our study, the association between long-term alcohol intake and risk of stomach cancer and its subtypes was evaluated. We performed a pooled analysis of data collected at baseline from 491 714 participants in the European Prospective Investigation into Cancer and Nutrition and the Melbourne Collaborative Cohort Study. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated for incident stomach cancer in relation to lifetime alcohol intake and group-based life course intake trajectories, adjusted for potential confounders including Helicobacter pylori infection. In all, 1225 incident stomach cancers (78% noncardia) were diagnosed over 7 094 637 person-years; 984 in 382 957 study participants with lifetime alcohol intake data (5 455 507 person-years). Although lifetime alcohol intake was not associated with overall stomach cancer risk, we observed a weak positive association with noncardia cancer (HR = 1.03, 95% CI: 1.00-1.06 per 10 g/d increment), with a HR of 1.50 (95% CI: 1.08-2.09) for ≥60 g/d compared to 0.1 to 4.9 g/d. A weak inverse association with cardia cancer (HR = 0.93, 95% CI: 0.87-1.00) was also observed. HRs of 1.48 (95% CI: 1.10-1.99) for noncardia and 0.51 (95% CI: 0.26-1.03) for cardia cancer were observed for a life course trajectory characterized by heavy decreasing intake compared to light stable intake (Phomogeneity = .02). These associations did not differ appreciably by smoking or H pylori infection status. Limiting alcohol use during lifetime, particularly avoiding heavy use during early adulthood, might help prevent noncardia stomach cancer. Heterogeneous associations observed for cardia and noncardia cancers may indicate etiologic differences.en_US
dc.identifier.citationJayasekara, MacInnis, Lujan-Barroso, Mayen-Chacon, Cross, Wallner, ... Ferrari. Lifetime alcohol intake, drinking patterns over time and risk of stomach cancer: A pooled analysis of data from two prospective cohort studies. International Journal of Cancer. 2021;148(11):2759-2773en_US
dc.identifier.cristinIDFRIDAID 1998704
dc.identifier.doi10.1002/ijc.33504
dc.identifier.issn0020-7136
dc.identifier.issn1097-0215
dc.identifier.urihttps://hdl.handle.net/10037/24167
dc.language.isoengen_US
dc.publisherWileyen_US
dc.relation.journalInternational Journal of Cancer
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2021 The Author(s)en_US
dc.titleLifetime alcohol intake, drinking patterns over time and risk of stomach cancer: A pooled analysis of data from two prospective cohort studiesen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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