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dc.contributor.authorReyes, Luis Felipe
dc.contributor.authorMurthy, Srinivas
dc.contributor.authorGarcia-Gallo, Esteban
dc.contributor.authorIrvine, Mike
dc.contributor.authorMerson, Laura
dc.contributor.authorMartin-Loeches, Ignacio
dc.contributor.authorRello, Jordi
dc.contributor.authorTaccone, Fabio S.
dc.contributor.authorFowler, Robert A.
dc.contributor.authorDocherty, Annemarie B.
dc.contributor.authorKartsonaki, Christiana
dc.contributor.authorAragao, Irene
dc.contributor.authorBarrett, Peter W.
dc.contributor.authorBeane, Abigail
dc.contributor.authorBurrell, Aidan J.C.
dc.contributor.authorCheng, Matthew Pellan
dc.contributor.authorChristian, Michael D.
dc.contributor.authorCidade, Jose Pedro
dc.contributor.authorCitarella, Barbara Wanjiru
dc.contributor.authorDonnelly, Christl A.
dc.contributor.authorFernandes, Susana M.
dc.contributor.authorFrench, Craig
dc.contributor.authorHaniffa, Rashan
dc.contributor.authorHarrison, Ewen M.
dc.contributor.authorHo, Antonia Ying Wai
dc.contributor.authorJoseph, Mark
dc.contributor.authorKhan, Irfan Ahmad
dc.contributor.authorKho, Michelle E.
dc.contributor.authorKildal, Anders Benjamin
dc.contributor.authorKutsogiannis, Demetrios
dc.contributor.authorLamontagne, François
dc.contributor.authorLee, Todd C.
dc.contributor.authorBassi, Gianluigi Li
dc.contributor.authorRevilla, Jose Wagner Lopez
dc.contributor.authorMarquis, Catherine
dc.contributor.authorMillar, Jonathan
dc.contributor.authorNeto, Raul
dc.contributor.authorNichol, Alistair
dc.contributor.authorParke, Rachael
dc.contributor.authorPereira, Rui
dc.contributor.authorPoli, Sergio
dc.contributor.authorPovoa, Pedro
dc.contributor.authorRamanathan, Kollengode
dc.contributor.authorRewa, Oleksa
dc.contributor.authorRiera, Jordi
dc.contributor.authorShrapnel, Sally
dc.contributor.authorSilva, Maria Joao
dc.contributor.authorUdy, Andrew
dc.contributor.authorUyeki, Timothy
dc.contributor.authorWebb, Steve A.
dc.contributor.authorWils, Evert-Jan
dc.contributor.authorRojek, Amanda
dc.contributor.authorOlliaro, Piero L.
dc.date.accessioned2022-03-04T09:54:14Z
dc.date.available2022-03-04T09:54:14Z
dc.date.issued2022-02-14
dc.description.abstractDue to the large number of patients with severe coronavirus disease 2019 (COVID-19), many were treated outside the traditional walls of the intensive care unit (ICU), and in many cases, by personnel who were not trained in critical care. The clinical characteristics and the relative impact of caring for severe COVID-19 patients outside the ICU is unknown. This was a multinational, multicentre, prospective cohort study embedded in the International Severe Acute Respiratory and Emerging Infection Consortium World Health Organization COVID-19 platform. Severe COVID-19 patients were identified as those admitted to an ICU and/or those treated with one of the following treatments: invasive or noninvasive mechanical ventilation, high-flow nasal cannula, inotropes or vasopressors. A logistic generalised additive model was used to compare clinical outcomes among patients admitted or not to the ICU. A total of 40 440 patients from 43 countries and six continents were included in this analysis. Severe COVID-19 patients were frequently male (62.9%), older adults (median (interquartile range (IQR), 67 (55–78) years), and with at least one comorbidity (63.2%). The overall median (IQR) length of hospital stay was 10 (5–19) days and was longer in patients admitted to an ICU than in those who were cared for outside the ICU (12 (6–23) days versus 8 (4–15) days, p<0.0001). The 28-day fatality ratio was lower in ICU-admitted patients (30.7% (5797 out of 18 831) versus 39.0% (7532 out of 19 295), p<0.0001). Patients admitted to an ICU had a significantly lower probability of death than those who were not (adjusted OR 0.70, 95% CI 0.65–0.75; p<0.0001). Patients with severe COVID-19 admitted to an ICU had significantly lower 28-day fatality ratio than those cared for outside an ICU.en_US
dc.identifier.citationReyes LF, Murthy S, Garcia-Gallo E, et al. Clinical characteristics, risk factors and outcomes in patients with severe COVID-19 registered in the International Severe Acute Respiratory and Emerging Infection Consortium WHO clinical characterisation protocol: a prospective, multinational, multicentre, observational study. ERJ Open Res 2022; 8: 00552-2021en_US
dc.identifier.cristinIDFRIDAID 1994439
dc.identifier.doi10.1183/23120541.00552-2021
dc.identifier.issn2312-0541
dc.identifier.urihttps://hdl.handle.net/10037/24258
dc.language.isoengen_US
dc.publisherEuropean Respiratory Societyen_US
dc.relation.journalEuropean Respiratory Journal Open Research (ERJ Open Research)
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/H2020/965313/Netherlands/European Clinical Research Alliance on Infectious Diseases/ECRAID-Base/en_US
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2022 The Author(s)en_US
dc.titleClinical characteristics, risk factors and outcomes in patients with severe COVID-19 registered in the International Severe Acute Respiratory and Emerging Infection Consortium WHO clinical characterisation protocol: a prospective, multinational, multicentre, observational studyen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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