Vis enkel innførsel

dc.contributor.authorSoltys, Marek
dc.contributor.authorZuza, David
dc.contributor.authorBoleslavska, Tereza
dc.contributor.authorAkhlasova, Sarah Machac
dc.contributor.authorBalouch, Martin
dc.contributor.authorKovacik, Pavel
dc.contributor.authorBeranek, Josef
dc.contributor.authorSkalko-Basnet, Natasa
dc.contributor.authorFlaten, Gøril Eide
dc.contributor.authorStefanec, Frantisek
dc.date.accessioned2022-03-29T12:15:08Z
dc.date.available2022-03-29T12:15:08Z
dc.date.issued2021-08-08
dc.description.abstractThe sorption of poorly aqueous soluble active pharmaceutical ingredients (API) to mesoporous silica carriers is an increasingly common formulation strategy for dissolution rate enhancement for this challenging group of substances. However, the success of this approach for a particular API depends on an array of factors including the properties of the porous carrier, the loading method, or the attempted mass fraction of the API. At present, there is no established methodology for the rational selection of these parameters. In the present work, we report a systematic comparison of four well-characterised silica carriers and seven APIs loaded by the same solvent evaporation method. In each case, we find the maximum amorphization capacity by x-ray powder diffraction analysis and measure the in vitro drug release kinetics. For a selected case, we also demonstrate the potential for bioavailability enhancement by a permeation essay.en_US
dc.identifier.citationSoltys M, Zuza, Boleslavska, Akhlasova, Balouch, Kovacik, Beranek, Skalko-Basnet N, Flaten gef, Stefanec. Drug loading to mesoporous silica carriers by solvent evaporation: A comparative study of amorphization capacity and release kinetics. International Journal of Pharmaceutics. 2021;607:12025en_US
dc.identifier.cristinIDFRIDAID 1928313
dc.identifier.doi10.1016/j.ijpharm.2021.120982
dc.identifier.issn0378-5173
dc.identifier.issn1873-3476
dc.identifier.urihttps://hdl.handle.net/10037/24631
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.relation.journalInternational Journal of Pharmaceutics
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2021 The Author(s)en_US
dc.titleDrug loading to mesoporous silica carriers by solvent evaporation: A comparative study of amorphization capacity and release kineticsen_US
dc.type.versionacceptedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


Tilhørende fil(er)

Thumbnail

Denne innførselen finnes i følgende samling(er)

Vis enkel innførsel