Show simple item record

dc.contributor.advisorBang, Berit
dc.contributor.authorNasir, Munawar Ahmad
dc.date.accessioned2010-05-14T11:44:42Z
dc.date.available2010-05-14T11:44:42Z
dc.date.issued2010-03-22
dc.description.abstractIn these studies, we focus on moricrase (enzyme mixture from hapatopancreas of king crab) as an activator of inflammatory responses in airway cells. Taking under consideration that serine proteases, such as trypsin, are stimulator of interlukin-8 (IL-8). We investigate the role of protease activated receptor 2 (PAR-2) in the inflammation of human pulmonary epithelial cells (A549). A549 cells were exposed to moricrase and we observed that moricrase induces stimulation of IL-8. Finally, it has been found that after the stimulation of A549 cells with moricrase, the release of IL-8 is mediated through the activation of PAR-2.With respect to our findings we can suggest that moricrase, via activation of PAR-2, might produce inflammation or influence the inflammatory process in human airways if inhaled in a significant amount.en
dc.format.extent983073 bytes
dc.format.mimetypeapplication/pdf
dc.identifier.urihttps://hdl.handle.net/10037/2470
dc.identifier.urnURN:NBN:no-uit_munin_2217
dc.language.isoengen
dc.publisherUniversitetet i Tromsøen
dc.publisherUniversity of Tromsøen
dc.rights.accessRightsopenAccess
dc.rights.holderCopyright 2010 The Author(s)
dc.subject.courseIDBIO-3930nor
dc.subjectVDP::Medical disciplines: 700::Health sciences: 800::Occupational health: 809en
dc.titleKing crab proteases: as stimulators of an inflammatory pathway in human airway epithelial cellsen
dc.typeMaster thesisen
dc.typeMastergradsoppgaveen


File(s) in this item

Thumbnail
Thumbnail

This item appears in the following collection(s)

Show simple item record