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dc.contributor.authorYang, Hannah P.
dc.contributor.authorCook, Linda S.
dc.contributor.authorWeiderpass, Elisabete
dc.contributor.authorAdami, Hans Olov
dc.contributor.authorAnderson, Kristin E.
dc.contributor.authorCai, Hui
dc.contributor.authorCerhan, James R.
dc.contributor.authorClendenen, Tess V.
dc.contributor.authorFelix, Ashley Sinclair
dc.contributor.authorFriedenreich, Christine Martha
dc.contributor.authorGarcía-Closas, Montserrat
dc.contributor.authorGoodman, Mark T.
dc.contributor.authorLiang, Xiaolin
dc.contributor.authorLissowska, Jolanta
dc.contributor.authorLu, Lichun
dc.contributor.authorMagliocco, Anthony Martin
dc.contributor.authorMccann, Susan E.
dc.contributor.authorMoysich, Kirsten Barbara
dc.contributor.authorOlson, Sara H.
dc.contributor.authorPetruzella, Stacey
dc.contributor.authorPike, Malcolm C.
dc.contributor.authorPolidoro, Silvia
dc.contributor.authorRicceri, Fulvio
dc.contributor.authorRisch, Harvey A.
dc.contributor.authorSacerdote, Carlotta
dc.contributor.authorSetiawan, Veronica Wendy
dc.contributor.authorShu, Xiao-Ou
dc.contributor.authorSpurdle, Amanda B.
dc.contributor.authorTrabert, Britton L.
dc.contributor.authorWebb, Penelope M.
dc.contributor.authorWentzensen, Nicolas
dc.contributor.authorXiang, Yong-Bing
dc.contributor.authorXu, Youming
dc.contributor.authorYu, Herbert
dc.contributor.authorZeleniuch-Jacquotte, Anne
dc.contributor.authorBrinton, Louise Annette
dc.date.accessioned2022-04-29T09:06:29Z
dc.date.available2022-04-29T09:06:29Z
dc.date.issued2015-02-17
dc.description.abstractBackground: Nulliparity is an endometrial cancer risk factor, but whether or not this association is due to infertility is unclear. Although there are many underlying infertility causes, few studies have assessed risk relations by specific causes.<p> <p>Methods: We conducted a pooled analysis of 8153 cases and 11 713 controls from 2 cohort and 12 case-control studies. All studies provided selfreported infertility and its causes, except for one study that relied on data from national registries. Logistic regression was used to estimate adjusted odds ratios (OR) and 95% confidence intervals (CI).<p> <p>Results: Nulliparous women had an elevated endometrial cancer risk compared with parous women, even after adjusting for infertility (OR ¼ 1.76; 95% CI: 1.59–1.94). Women who reported infertility had an increased risk compared with those without infertility concerns, even after adjusting for nulliparity (OR ¼ 1.22; 95% CI: 1.13–1.33). Among women who reported infertility, none of the individual infertility causes were substantially related to endometrial cancer.<p> <p>Conclusions: Based on mainly self-reported infertility data that used study-specific definitions of infertility, nulliparity and infertility appeared to independently contribute to endometrial cancer risk. Understanding residual endometrial cancer risk related to infertility, its causes and its treatments may benefit from large studies involving detailed data on various infertility parameters.en_US
dc.identifier.citationYang HP, Cook LS, Weiderpass E, Adami HO, Anderson, Cai H, Cerhan JR, Clendenen, Felix, Friedenreich, García-Closas M, Goodman, Liang X, Lissowska J, Lu, Magliocco, Mccann, Moysich, Olson SH, Petruzella, Pike MC, Polidoro S, Ricceri F, Risch HA, Sacerdote C, Setiawan VW, Shu X, Spurdle AB, Trabert, Webb PM, Wentzensen N, Xiang Y, Xu, Yu H, Zeleniuch-Jacquotte A, Brinton LA. Infertility and incident endometrial cancer risk: A pooled analysis from the epidemiology of endometrial cancer consortium (E2C2). British Journal of Cancer. 2015;112(5):925-933en_US
dc.identifier.cristinIDFRIDAID 1278034
dc.identifier.doi10.1038/bjc.2015.24
dc.identifier.issn0007-0920
dc.identifier.issn1532-1827
dc.identifier.urihttps://hdl.handle.net/10037/24943
dc.language.isoengen_US
dc.publisherSpringer Natureen_US
dc.relation.journalBritish Journal of Cancer
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2015 The Author(s)en_US
dc.titleInfertility and incident endometrial cancer risk: A pooled analysis from the epidemiology of endometrial cancer consortium (E2C2)en_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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