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dc.contributor.authorBamia, Christina
dc.contributor.authorLagiou, Pagona
dc.contributor.authorJenab, Mazda
dc.contributor.authorAleksandrova, Krasimira
dc.contributor.authorFedirko, Veronika
dc.contributor.authorTrichopoulos, Dimitrios
dc.contributor.authorOvervad, Kim
dc.contributor.authorTjønneland, Anne
dc.contributor.authorOlsen, Anja
dc.contributor.authorClavel-Chapelon, Françoise
dc.contributor.authorBoutron-Ruault, Marie-Christine
dc.contributor.authorKvaskoff, Marina
dc.contributor.authorKatzke, Verena A.
dc.contributor.authorKühn, Tilman
dc.contributor.authorBoeing, Heiner
dc.contributor.authorNöthlings, Ute
dc.contributor.authorPalli, Domenico
dc.contributor.authorSieri, Sabina
dc.contributor.authorPanico, Salvatore
dc.contributor.authorTumino, Rosaria
dc.contributor.authorNaccarati, Allessio
dc.contributor.authorBueno-de-Mesquita, H. Bas
dc.contributor.authorPeeters, Petra H.M.
dc.contributor.authorWeiderpass, Elisabete
dc.contributor.authorSkeie, Guri
dc.contributor.authorQuirós, José Ramón
dc.contributor.authorAgudo, Antonio
dc.contributor.authorChirlaque, María-Dolores
dc.contributor.authorSánchez, María-José
dc.contributor.authorArdanaz, Eva
dc.contributor.authorDorronsoro, Miren
dc.contributor.authorEricson, Ulrika
dc.contributor.authorNilsson, Lena Maria
dc.contributor.authorWennberg, Maria
dc.contributor.authorKhaw, Kay-Tee
dc.contributor.authorWareham, Nicholas J.
dc.contributor.authorKey, Timothy J.
dc.contributor.authorTravis, Ruth C.
dc.contributor.authorFerrari, Pietro
dc.contributor.authorStepien, Magdalena
dc.contributor.authorDuarte-Salles, Talita
dc.contributor.authorNorat, Teresa
dc.contributor.authorMurphy, Neil
dc.contributor.authorRiboli, Eilo
dc.contributor.authorTrichopoulou, Antonia
dc.date.accessioned2022-04-29T10:33:53Z
dc.date.available2022-04-29T10:33:53Z
dc.date.issued2015-03-05
dc.description.abstractBackground: Vegetable and/or fruit intakes in association with hepatocellular carcinoma (HCC) risk have been investigated in case–control studies conducted in specific European countries and cohort studies conducted in Asia, with inconclusive results. No multi-centre European cohort has investigated the indicated associations. Methods: In 486 799 men/women from the European Prospective Investigation into Cancer and nutrition, we identified 201 HCC cases after 11 years median follow-up. We calculated adjusted hazard ratios (HRs) for HCC incidence for sex-specific quintiles and per 100 g d <sup> -1</sup> increments of vegetable/fruit intakes. Results: Higher vegetable intake was associated with a statistically significant, monotonic reduction of HCC risk: HR (100 g d <sup>-1</sup> increment): 0.83; 95% CI: 0.71–0.98. This association was consistent in sensitivity analyses with no apparent heterogeneity across strata of HCC risk factors. Fruit intake was not associated with HCC incidence: HR (100 g d <sup> -1</sup> increment): 1.01; 95% CI: 0.92–1.11. Conclusions: Vegetable, but not fruit, intake is associated with lower HCC risk with no evidence for heterogeneity of this association in strata of important HCC risk factors. Mechanistic studies should clarify pathways underlying this association. Given that HCC prognosis is poor and that vegetables are practically universally accessible, our results may be important, especially for those at high risk for the disease.en_US
dc.identifier.citationBamia C, Lagiou P, Jenab M, Aleksandrova K, Fedirko V, Trichopoulos D, Overvad K, Tjønneland A, Olsen A, Clavel-Chapelon F, Boutron-Ruault M, Kvaskoff M, Katzke VA, Kühn T, Boeing H, Nöthlings U, Palli D, Sieri S, Panico S, Tumino R, Naccarati A, Bueno-de-Mesquita HB, Peeters PH, Weiderpass E, Skeie G, Quirós JR, Agudo A, Chirlaque M, Sánchez M, Ardanaz E, Dorronsoro M, Ericson U, Nilsson LM, Wennberg M, Khaw K, Wareham NJ, Key TJ, Travis RC, Ferrari P, Stepien M, Duarte-Salles T, Norat T, Murphy N, Riboli E, Trichopoulou A. Fruit and vegetable consumption in relation to hepatocellular carcinoma in a multi-centre, European cohort study. British Journal of Cancer. 2015;112(7):1273-1282en_US
dc.identifier.cristinIDFRIDAID 1280278
dc.identifier.doi10.1038/bjc.2014.654
dc.identifier.issn0007-0920
dc.identifier.issn1532-1827
dc.identifier.urihttps://hdl.handle.net/10037/24946
dc.language.isoengen_US
dc.publisherWileyen_US
dc.relation.journalBritish Journal of Cancer
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2015 The Author(s)en_US
dc.titleFruit and vegetable consumption in relation to hepatocellular carcinoma in a multi-centre, European cohort studyen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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