Insulin-like growth factor I and risk of epithelial invasive ovarian cancer by tumour characteristics: Results from the EPIC cohort

Permanent lenke
https://hdl.handle.net/10037/24962
DOI
https://doi.org/10.1038/bjc.2014.566
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Dato
2014-11-04
Type
Journal article
Tidsskriftartikkel
Peer reviewed

Forfatter
Ose, Jennifer; Fortner, Renée T; Schock, Helena; Peeters, Petra H.; Onland-Moret, N. Charlotte; Bueno-de-Mesquita, H. Bas; Weiderpass, Elisabete; Gram, Inger Torhild; Overvad, Kim; Tjønneland, Anne; Dossus, Laure; Fournier, Agnes; Baglietto, Laura; Trichopoulou, Antonia; Benetou, Vassiliki; Trichopoulos, Dimitrios; Boeing, Heiner; Masala, Giovanna; Krogh, Vittorio; Matiello, Amalia; Tumino, Rosaria; Popovic, Maja; Obón-Santacana, Mireia; Larrañaga, Nerea; Ardanaz, Eva; Sánchez, María-José; Menéndez, Virginia; Chirlaque, María-Dolores; Travis, Ruth C.; Khaw, Kay-Tee; Brändstedt, Jenny; Idahl, Annika; Lundin, Eva; Rinaldi, Sabina; Kuhn, Elisabetta; Romieu, Isabelle; Gunter, Marc J.; Merritt, Melissa A.; Riboli, Elio; Kaaks, Rudolf
Sammendrag
Background: Prospective studies on insulin-like growth factor I (IGF-I) and epithelial ovarian cancer (EOC) risk are inconclusive. Data suggest risk associations vary by tumour characteristics.

Methods: We conducted a nested case–control study in the European Prospective Investigation into Cancer and Nutrition (EPIC) to evaluate IGF-I concentrations and EOC risk by tumour characteristics (n ¼ 565 cases). Multivariable conditional logistic regression models were used to estimate associations.

Results: We observed no association between IGF-I and EOC overall or by tumour characteristics.

Conclusions: In the largest prospective study to date was no association between IGF-I and EOC risk. Pre-diagnostic serum IGF-I concentrations may not influence EOC risk.

Forlag
Springer Nature
Sitering
Ose J, Fortner RT, Schock H, Peeters PH, Onland-Moret NC, Bueno-de-Mesquita HB, Weiderpass E, Gram IT, Overvad K, Tjønneland A, Dossus L, Fournier A, Baglietto L, Trichopoulou A, Benetou V, Trichopoulos D, Boeing H, Masala G, Krogh V, Matiello A, Tumino R, Popovic, Obón-Santacana M, Larrañaga N, Ardanaz E, Sánchez M, Menéndez, Chirlaque M, Travis RC, Khaw K, Brändstedt, Idahl A, Lundin E, Rinaldi S, Kuhn, Romieu I, Gunter MJ, Merritt, Riboli E, Kaaks R. Insulin-like growth factor I and risk of epithelial invasive ovarian cancer by tumour characteristics: Results from the EPIC cohort. British Journal of Cancer. 2015;112(1):162-166
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Copyright 2015 Cancer Research UK.