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dc.contributor.authorSen, Abhijit
dc.contributor.authorTsilidis, Konstantinos K.
dc.contributor.authorAllen, Naomi E.
dc.contributor.authorRinaldi, Sabina
dc.contributor.authorAppleby, Paul N.
dc.contributor.authorAlmquist, Martin
dc.contributor.authorSchmidt, Julie A.
dc.contributor.authorDahm, Christina C.
dc.contributor.authorOvervad, Kim
dc.contributor.authorTjønneland, Anne
dc.contributor.authorRostgaard-Hansen, Agnetha L.
dc.contributor.authorClavel-Chapelon, Françoise
dc.contributor.authorBaglietto, Laura
dc.contributor.authorBoutron-Ruault, Marie-Christine
dc.contributor.authorKühn, Tilman
dc.contributor.authorKatze, Verena A.
dc.contributor.authorBoeing, Heiner
dc.contributor.authorTrichopoulou, Antonia
dc.contributor.authorTsironis, Christos
dc.contributor.authorLagiou, Pagona
dc.contributor.authorPalli, Domenico
dc.contributor.authorPala, Valeria
dc.contributor.authorPanico, Salvatore
dc.contributor.authorTumino, Rosario
dc.contributor.authorVineis, Paolo
dc.contributor.authorBueno-de-Mesquita, H. Bas
dc.contributor.authorPeeters, Petra H.
dc.contributor.authorHjartåker, Anette
dc.contributor.authorLund, Eiliv
dc.contributor.authorWeiderpass, Elisabete
dc.contributor.authorQuirós, J. Ramón
dc.contributor.authorAgudo, Antonio
dc.contributor.authorSánchez, Mariá-José
dc.contributor.authorArriola, Larraitz
dc.contributor.authorGavrila, Diana
dc.contributor.authorGurrea, Aurelio Barricarte
dc.contributor.authorTosovic, Ada
dc.contributor.authorHennings, Joakim
dc.contributor.authorSandström, Maria
dc.contributor.authorRomieu, Isabelle
dc.contributor.authorFerrari, Pietro
dc.contributor.authorZamora-Ros, Raul
dc.contributor.authorKhaw, Kay-Tee
dc.contributor.authorWareham, Nicholas J.
dc.contributor.authorRiboli, Elio
dc.contributor.authorGunter, Marc
dc.contributor.authorFranceschi, Silvia
dc.date.accessioned2022-05-02T08:58:32Z
dc.date.available2022-05-02T08:58:32Z
dc.date.issued2015-08-27
dc.description.abstractBackground: Results from several cohort and case–control studies suggest a protective association between current alcohol intake and risk of thyroid carcinoma, but the epidemiological evidence is not completely consistent and several questions remain unanswered.<p> <p>Methods: The association between alcohol consumption at recruitment and over the lifetime and risk of differentiated thyroid carcinoma was examined in the European Prospective Investigation into Cancer and Nutrition. Among 477 263 eligible participants (70% women), 556 (90% women) were diagnosed with differentiated thyroid carcinoma over a mean follow-up of 11 years. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using multivariable Cox proportional hazards models.<p> <p>Results: Compared with participants consuming 0.1–4.9 g of alcohol per day at recruitment, participants consuming 15 or more grams (approximately 1–1.5 drinks) had a 23% lower risk of differentiated thyroid carcinoma (HR ¼ 0.77; 95% CI ¼ 0.60–0.98). These findings did not differ greatly when analyses were conducted for lifetime alcohol consumption, although the risk estimates were attenuated and not statistically significant anymore. Similar results were observed by type of alcoholic beverage, by differentiated thyroid carcinoma histology or according to age, sex, smoking status, body mass index and diabetes.<p> <p<Conclusions: Our study provides some support to the hypothesis that moderate alcohol consumption may be associated with a lower risk of papillary and follicular thyroid carcinomas.en_US
dc.identifier.citationSen A, Tsilidis KK, Allen NE, Rinaldi S, Appleby PN, Almquist M, Schmidt JA, Dahm CC, Overvad K, Tjønneland A, Rostgaard-Hansen, Clavel-Chapelon F, Baglietto L, Boutron-Ruault M, Kühn T, Katze, Boeing H, Trichopoulou A, Tsironis C, Lagiou P, Palli D, Pala V, Panico S, Tumino R, Vineis P, Bueno-de-Mesquita HB, Peeters PH, Hjartåker A, Lund e, Weiderpass E, Quirós JR, Agudo A, Sánchez M, Arriola L, Gavrila D, Gurrea AB, Tosovic, Hennings J, Sandström M, Romieu I, Ferrari P, Zamora-Ros R, Khaw K, Wareham NJ, Riboli E, Gunter M, Franceschi S. Baseline and lifetime alcohol consumption and risk of differentiated thyroid carcinoma in the EPIC study. British Journal of Cancer. 2015;113(5):840-847en_US
dc.identifier.cristinIDFRIDAID 1285327
dc.identifier.doi10.1038/bjc.2015.280
dc.identifier.issn0007-0920
dc.identifier.issn1532-1827
dc.identifier.urihttps://hdl.handle.net/10037/24964
dc.language.isoengen_US
dc.relation.journalBritish Journal of Cancer
dc.relation.urihttp://www.nature.com/bjc/journal/v113/n5/pdf/bjc2015280a.pdf
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2015 Cancer Research UK.en_US
dc.titleBaseline and lifetime alcohol consumption and risk of differentiated thyroid carcinoma in the EPIC studyen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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